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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 15218naa a2204741 4500 | |
| 001 | oai:gup.ub.gu.se/277524 | |
| 003 | SwePub | |
| 008 | 240528s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2775242 URI |
| 024 | 7 | a https://doi.org/10.1212/nxg.00000000000002932 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Pulit, S. L.4 aut |
| 245 | 1 0 | a Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes |
| 264 | c 2018-12-03 | |
| 264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2018 |
| 520 | a Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a ischemic-stroke | |
| 653 | a causative classification | |
| 653 | a lifetime risk | |
| 653 | a epidemiology | |
| 653 | a association | |
| 653 | a prevention | |
| 653 | a variants | |
| 653 | a aspirin | |
| 653 | a burden | |
| 653 | a Neurosciences & Neurology | |
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| 700 | 1 | a Pedersen, Annie,d 1981u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut0 (Swepub:gu)xpeder |
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| 700 | 1 | a Atrial Fibrillation Genetics Conso; Int Stroke Genetics, Consortium4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för biomedicin4 org |
| 773 | 0 | t Neurology-Geneticsd : Ovid Technologies (Wolters Kluwer Health)g 4:6q 4:6x 2376-7839 |
| 856 | 4 | u https://ng.neurology.org/content/nng/4/6/e293.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/277524 |
| 856 | 4 8 | u https://doi.org/10.1212/nxg.0000000000000293 |
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