Search: WFRF:(Öhman Jenny)
> (2015-2019) >
Combined Testing of...
Combined Testing of p16 Tumour-suppressor Protein and Human Papillomavirus in Patients With Oral Leukoplakia and Oral Squamous Cell Carcinoma.
-
- Sundberg, Jonas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, POB 450, SE-40530 Gothenburg, Sweden
-
- Korytowska, Magdalena (author)
- NAL Hosp, Clin Orofacial Med & Maxillofacial Surg, Trollhattan, Sweden
-
- Burgos, Patricia Miranda (author)
- NAL Hosp, Clin Orofacial Med & Maxillofacial Surg, Trollhattan, Sweden
-
show more...
-
- Blomgren, Johan (author)
- Sahlgrenska Univ Hosp East, Clin Orofacial Med, Gothenburg, Sweden
-
- Blomstrand, Lena (author)
- Uppsala universitet,Käkkirurgi
-
- DE Lara, Shahin (author)
- Sahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg, Sweden
-
- Sand, Lars (author)
- Univ Oslo, Fac Odontol, Dept Oral Biol, Oslo, Norway
-
- Hirsch, Jan-Michael (author)
- Uppsala universitet,Käkkirurgi
-
- Holmberg, Erik, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden
-
- Giglio, Daniel, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden
-
- Öhman, Jenny (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, POB 450, SE-40530 Gothenburg, Sweden
-
- Kovács, Anikó, 1961 (author)
- Sahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg, Sweden
-
- Horal, Peter, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Med, Gothenburg, Sweden
-
- Lindh, Magnus, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Med, Gothenburg, Sweden
-
- Kjeller, Göran (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Dept Oral & Maxillofacial Surg, Gothenburg, Sweden
-
- Hasséus, Bengt, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, POB 450, SE-40530 Gothenburg, Sweden
-
show less...
-
(creator_code:org_t)
- 2019-03-06
- 2019
- English.
-
In: Anticancer research. - : Anticancer Research USA Inc.. - 1791-7530 .- 0250-7005. ; 39:3, s. 1293-1300
- Related links:
-
http://ar.iiarjourna...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.2...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Oral leukoplakia (OL) is a potentially malignant oral mucosal disorder. A casual association between OL, oral squamous cell carcinoma (OSCC) and human papillomavirus (HPV) infection has been suggested, but no conclusive evidence has been presented. p16, a tumour-suppressor protein, is used as a surrogate marker for HPV infection. The aim of this study was to investigate how overexpression of p16 correlates with HPV infection in OL and in OSCC.Seventy-four patients with OL and 13 with OSCC with p16 overexpressed, were analyzed by immunohistochemistry visualizing p16 and a real-time polymerase chain reaction (PCR) assay targeting HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 52, 56, 58 and 59.Overexpression of p16 was observed in 18% of patients with OL. None of the HPV subtypes were detected by PCR analysis in patients with OL. In the p16-positive OSCC specimens, 38% were also HPV16-positive.Overexpression of p16 was not found to be a reliable biomarker for HPV infection in patients with OL and OSCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adult
- Aged
- Aged
- 80 and over
- Carcinoma
- Squamous Cell
- metabolism
- virology
- Cyclin-Dependent Kinase Inhibitor p16
- metabolism
- DNA
- Viral
- analysis
- Female
- Humans
- Leukoplakia
- Oral
- metabolism
- virology
- Male
- Middle Aged
- Mouth Neoplasms
- metabolism
- virology
- Papillomaviridae
- genetics
- Papillomavirus Infections
- metabolism
- virology
- Potentially malignant oral disorders
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sundberg, Jonas
-
Korytowska, Magd ...
-
Burgos, Patricia ...
-
Blomgren, Johan
-
Blomstrand, Lena
-
DE Lara, Shahin
-
show more...
-
Sand, Lars
-
Hirsch, Jan-Mich ...
-
Holmberg, Erik, ...
-
Giglio, Daniel, ...
-
Öhman, Jenny
-
Kovács, Anikó, 1 ...
-
Horal, Peter, 19 ...
-
Lindh, Magnus, 1 ...
-
Kjeller, Göran
-
Hasséus, Bengt, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Dentistry
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Anticancer resea ...
- By the university
-
University of Gothenburg
-
Uppsala University