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Genetic and lifesty...
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
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Chauhan, G. (author)
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Adams, H. H. H. (author)
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Satizabal, C. L. (author)
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show more...
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Bis, J. C. (author)
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Teumer, A. (author)
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Sargurupremraj, M. (author)
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Hofer, E. (author)
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Trompet, S. (author)
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Hilal, S. (author)
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Smith, A. V. (author)
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Jian, X. Q. (author)
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Malik, R. (author)
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Traylor, M. (author)
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Pulit, S. L. (author)
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Amouyel, P. (author)
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Mazoyer, B. (author)
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Zhu, Y. C. (author)
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Kaffashian, S. (author)
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Schilling, S. (author)
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Beecham, G. W. (author)
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Montine, T. J. (author)
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Schellenberg, G. D. (author)
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Kjartansson, O. (author)
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Gudnason, V. (author)
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Knopman, D. S. (author)
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Griswold, M. E. (author)
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Windham, B. G. (author)
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Gottesman, R. F. (author)
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Mosley, T. H. (author)
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Schmidt, R. (author)
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Saba, Y. (author)
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Schmidt, H. (author)
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Takeuchi, F. (author)
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Yamaguchi, S. (author)
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Nabika, T. (author)
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Kato, N. (author)
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Rajan, K. B. (author)
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Aggarwal, N. T. (author)
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De Jager, P. L. (author)
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Evans, D. A. (author)
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Psaty, B. M. (author)
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Rotter, J. I. (author)
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Rice, K. (author)
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Lopez, O. L. (author)
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Liao, J. M. (author)
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Chen, C. (author)
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Cheng, C. Y. (author)
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Wong, T. Y. (author)
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Ikram, M. K. (author)
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van der Lee, S. J. (author)
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Amin, N. (author)
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Chouraki, V. (author)
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DeStefano, A. L. (author)
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Aparicio, H. J. (author)
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Romero, J. R. (author)
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Maillard, P. (author)
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DeCarli, C. (author)
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Wardlaw, J. M. (author)
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Hernandez, M. D. V. (author)
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Luciano, M. (author)
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Liewald, D. (author)
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Deary, I. J. (author)
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Starr, J. M. (author)
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Bastin, M. E. (author)
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Maniega, S. M. (author)
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Slagboom, P. E. (author)
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Beekman, M. (author)
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Deelen, J. (author)
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Uh, H. W. (author)
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Lemmens, R. (author)
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Brodaty, H. (author)
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Wright, M. J. (author)
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Ames, D. (author)
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Boncoraglio, G. B. (author)
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Hopewell, J. C. (author)
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Beecham, A. H. (author)
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Blanton, S. H. (author)
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Wright, C. B. (author)
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Sacco, R. L. (author)
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Wen, W. (author)
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Thalamuthu, A. (author)
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Armstrong, N. J. (author)
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Chong, E. (author)
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Schofield, P. R. (author)
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Kwok, J. B. (author)
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van der Grond, J. (author)
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Stott, D. J. (author)
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Ford, I. (author)
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Jukema, J. W. (author)
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Vernooij, M. W. (author)
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Hofman, A. (author)
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Uitterlinden, A. G. (author)
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van der Lugt, A. (author)
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Wittfeld, K. (author)
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Grabe, H. J. (author)
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Hosten, N. (author)
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von Sarnowski, B. (author)
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Volker, U. (author)
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Levi, C. (author)
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Jimenez-Conde, J. (author)
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Sharma, P. (author)
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Sudlow, C. L. M. (author)
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Rosand, J. (author)
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Woo, D. (author)
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Cole, J. W. (author)
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Meschia, J. F. (author)
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Slowik, A. (author)
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Thijs, V. (author)
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Lindgren, A. (author)
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Melander, O. (author)
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Grewal, R. P. (author)
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Rundek, T. (author)
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Rexrode, K. (author)
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Rothwell, P. M. (author)
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Arnett, D. K. (author)
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Johnson, J. A. (author)
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Benavente, O. R. (author)
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Wasssertheil-Smoller, S. (author)
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Lee, J. M. (author)
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Wong, Q. (author)
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Mitchell, B. D. (author)
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Rich, S. S. (author)
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McArdle, P. F. (author)
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Geerlings, M. I. (author)
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van der Graaf, Y. (author)
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de Bakker, P. I. W. (author)
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Asselbergs, F. W. (author)
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Srikanth, V. (author)
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Thomson, R. (author)
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McWhirter, R. (author)
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Moran, C. (author)
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Callisaya, M. (author)
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Phan, T. (author)
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Rutten-Jacobs, L. C. A. (author)
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Bevan, S. (author)
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Tzourio, C. (author)
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Mather, K. A. (author)
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Sachdev, P. S. (author)
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van Duijn, C. M. (author)
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Worrall, B. B. (author)
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Dichgans, M. (author)
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Kittner, S. J. (author)
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Markus, H. S. (author)
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Ikram, M. A. (author)
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Fornage, M. (author)
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Launer, L. J. (author)
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Seshadri, S. (author)
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Longstreth, W. T. (author)
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Debette, S. (author)
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Stroke Genetics Network Si, G. N. Isgc Metastroke Adgc Charge Consortium (author)
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(creator_code:org_t)
- 2019-01-16
- 2019
- English.
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In: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 92:5
- Related links:
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https://n.neurology....
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show more...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- ObjectiveTo explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts.MethodsWe performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n = 20,949) from 5 ethnicities (3,726 with BI, 2,021 with SSBI). Top loci were followed up in 7 population-based cohorts (n = 6,862; 1,483 with BI, 630 with SBBI), and we tested associations with related phenotypes including ischemic stroke and pathologically defined BI.ResultsThe mean prevalence was 17.7% for BI and 10.5% for SSBI, steeply rising after age 65. Two loci showed genome-wide significant association with BI: FBN2, p = 1.77 x 10(-8); and LINC00539/ZDHHC20, p = 5.82 x 10(-9). Both have been associated with blood pressure (BP)-related phenotypes, but did not replicate in the smaller follow-up sample or show associations with related phenotypes. Age- and sex-adjusted associations with BI and SSBI were observed for BP traits (p value for BI, p([BI]) = 9.38 x 10(-25); p([SSBI]) = 5.23 x 10(-14) for hypertension), smoking (p([BI]) = 4.4 x 10(-10); p([SSBI]) = 1.2 x 10(-4)), diabetes (p([BI]) = 1.7 x 10(-8); p([SSBI]) = 2.8 x 10(-3)), previous cardiovascular disease (p([BI]) = 1.0 x 10(-18); p([SSBI]) = 2.3 x 10(-7)), stroke (p([BI]) = 3.9 x 10(-69); p([SSBI]) = 3.2 x 10(-24)), and MRI-defined white matter hyperintensity burden (p([BI]) = 1.43 x 10(-157); p([SSBI]) = 3.16 x 10(-106)), but not with body mass index or cholesterol. GRS of BP traits were associated with BI and SSBI (p 0.0022), without indication of directional pleiotropy.ConclusionIn this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significant modifiable, causal risk factor for BI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- genome-wide association
- matter hyperintensity volume
- small vessel
- disease
- mendelian randomization
- ischemic-stroke
- blood-pressure
- silent
- metaanalysis
- polymorphisms
- insights
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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To the university's database
- By the author/editor
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Chauhan, G.
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Adams, H. H. H.
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Satizabal, C. L.
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Bis, J. C.
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Teumer, A.
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Sargurupremraj, ...
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show more...
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Hofer, E.
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Trompet, S.
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Hilal, S.
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Smith, A. V.
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Jian, X. Q.
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Malik, R.
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Traylor, M.
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Pulit, S. L.
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Amouyel, P.
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Mazoyer, B.
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Zhu, Y. C.
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Kaffashian, S.
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Schilling, S.
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Beecham, G. W.
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Montine, T. J.
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Schellenberg, G. ...
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Kjartansson, O.
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Gudnason, V.
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Knopman, D. S.
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Griswold, M. E.
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Windham, B. G.
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Gottesman, R. F.
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Mosley, T. H.
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Schmidt, R.
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Saba, Y.
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Schmidt, H.
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Takeuchi, F.
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Yamaguchi, S.
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Nabika, T.
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Kato, N.
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Rajan, K. B.
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Aggarwal, N. T.
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De Jager, P. L.
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Evans, D. A.
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Psaty, B. M.
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Rotter, J. I.
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Rice, K.
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Lopez, O. L.
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Liao, J. M.
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Chen, C.
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Cheng, C. Y.
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Wong, T. Y.
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Ikram, M. K.
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van der Lee, S. ...
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Amin, N.
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Chouraki, V.
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DeStefano, A. L.
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Aparicio, H. J.
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Romero, J. R.
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Maillard, P.
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DeCarli, C.
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Wardlaw, J. M.
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Hernandez, M. D. ...
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Luciano, M.
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Liewald, D.
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Deary, I. J.
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Starr, J. M.
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Bastin, M. E.
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Maniega, S. M.
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Slagboom, P. E.
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Beekman, M.
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Deelen, J.
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Uh, H. W.
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Lemmens, R.
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Brodaty, H.
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Wright, M. J.
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Ames, D.
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Boncoraglio, G. ...
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Hopewell, J. C.
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Beecham, A. H.
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Blanton, S. H.
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Wright, C. B.
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Sacco, R. L.
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Wen, W.
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Thalamuthu, A.
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Armstrong, N. J.
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Chong, E.
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Schofield, P. R.
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Kwok, J. B.
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van der Grond, J ...
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Stott, D. J.
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Ford, I.
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Jukema, J. W.
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Vernooij, M. W.
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Hofman, A.
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Uitterlinden, A. ...
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van der Lugt, A.
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Wittfeld, K.
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Grabe, H. J.
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Hosten, N.
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von Sarnowski, B ...
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Volker, U.
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Levi, C.
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Jimenez-Conde, J ...
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Sharma, P.
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Sudlow, C. L. M.
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Rosand, J.
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Woo, D.
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Cole, J. W.
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Meschia, J. F.
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Slowik, A.
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Thijs, V.
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Lindgren, A.
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Melander, O.
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Grewal, R. P.
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Rundek, T.
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Rexrode, K.
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Rothwell, P. M.
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Arnett, D. K.
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Jern, Christina, ...
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Johnson, J. A.
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Benavente, O. R.
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Wasssertheil-Smo ...
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Lee, J. M.
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Wong, Q.
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Mitchell, B. D.
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Rich, S. S.
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McArdle, P. F.
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Geerlings, M. I.
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van der Graaf, Y ...
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de Bakker, P. I. ...
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Asselbergs, F. W ...
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Srikanth, V.
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Thomson, R.
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McWhirter, R.
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Moran, C.
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Callisaya, M.
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Phan, T.
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Rutten-Jacobs, L ...
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Bevan, S.
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Tzourio, C.
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Mather, K. A.
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Sachdev, P. S.
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van Duijn, C. M.
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Worrall, B. B.
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Dichgans, M.
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Kittner, S. J.
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Markus, H. S.
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Ikram, M. A.
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Fornage, M.
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Launer, L. J.
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Seshadri, S.
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Longstreth, W. T ...
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Debette, S.
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Stroke Genetics ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg