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The Ki67 index a prognostic marker in medullary thyroid carcinoma.

Tisell, L E (author)
Oden, A (author)
Muth, A (author)
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Altiparmak, G (author)
Mölne, Johan, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
Ahlman, H (author)
Nilsson, O (author)
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 (creator_code:org_t)
2003-11-25
2003
English.
In: British journal of cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 89:11, s. 2093-7
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Our objective was to examine the usefulness of the Ki67 proliferation index as a prognostic marker in patients with medullary thyroid carcinoma (MTC). It is difficult to predict the prognosis of MTC by using conventional prognostic factors. Immunocytochemical analysis of tumour proliferation has been used as a prognostic tool in some tumours, but only rarely in MTC. In all, 71 tumours from 36 patients were investigated, by using a semiautomatic image analysis programme. On average 10,000 nuclear profiles were counted per tumour, and the percentage of tumour cells expressing the proliferation marker, Ki67, was calculated. Primary tumours that had metastasised had higher Ki67 indices than primary tumours that had not metastasised. Recurrent lymph node metastasis had higher Ki67 indices than the primary tumours. By using a Poisson model, it was possible to estimate the median survival time for individual patients if the Ki67 index for the primary tumour and the age at surgery were known. The higher the Ki67 index and the age at operation were, the shorter was the survival. Estimating the median survival of individual patients will be of help for planning the patients' life and postoperative follow-up and treatment.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Keyword

Adult
Biomarkers
Tumor
analysis
Carcinoma
Medullary
diagnosis
Female
Humans
Immunohistochemistry
Ki-67 Antigen
analysis
Lymph Node Excision
Male
Middle Aged
Prognosis
Thyroid Neoplasms
diagnosis
Thyroidectomy
Tumor Suppressor Protein p53
analysis

Publication and Content Type

ref (subject category)
art (subject category)

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