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Non-polarized cell ...
Non-polarized cell surface expression of HLA-A,B,C and HLA-DR antigens in Graves' thyroid follicle cells.
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- Mölne, Johan, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
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Nilsson, M (författare)
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Jansson, S (författare)
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visa fler...
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Hansson, G (författare)
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Ericson, L E (författare)
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visa färre...
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(creator_code:org_t)
- 1991
- 1991
- Engelska.
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Ingår i: Autoimmunity. - 0891-6934. ; 10:3, s. 189-99
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The intrathyroidal distribution and cell surface location of HLA-A,B,C and HLA-DR antigens was studied in polarized thyroid follicle cells from Graves' (n = 11) and normal (n = 3) thyroid tissue, using light and electron microscopy. Cryosections and isolated, open follicle segments were incubated with monoclonal antibodies against HLA-A,B,C and HLA-DR antigens and with patient sera containing autoantibodies against the microsomal antigen/thyroperoxidase. Immunoreactivity for HLA-A,B,C and HLA-DR on isolated thyroid follicle cells was frequently detected in Graves' disease, but absent in normal glands. There was a large variation in the immunolabelling between follicles as well as between different glands. Both HLA-A,B,C and HLA-DR immunoreactivity were detected on the apical and the basal surface of the follicle cells. Microsomal antigen/thyroperoxidase immunoreactivity was restricted to the apical cell surface. In contrast to normal tissue, HLA-DR positive cells with a dendritic or macrophage-like morphology were frequent in Graves' tissue. These cells adhered directly to the basal surface of isolated follicle segments. We conclude that HLA antigens are, unlike thyroid-specific plasma membrane constituents, expressed in a non-polarized manner at the surface of the follicular epithelium. These observations might have implications on the immune recognition of thyroidal autoantigens in Graves' disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Adult
- Aged
- Antigen-Presenting Cells
- immunology
- Cells
- Cultured
- Endothelium
- Vascular
- immunology
- Female
- Graves Disease
- immunology
- HLA-A Antigens
- analysis
- HLA-B Antigens
- analysis
- HLA-C Antigens
- analysis
- HLA-DR Antigens
- analysis
- Humans
- Immunohistochemistry
- Macrophages
- immunology
- Male
- Middle Aged
- Thyroid Gland
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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