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  • Rydén, LisaLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Lund University Hospital (author)

Reproducibility of human epidermal growth factor receptor 2 analysis in primary breast cancer: a national survey performed at pathology departments in Sweden.

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-08-13
  • Informa UK Limited,2009

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/280414
  • https://gup.ub.gu.se/publication/280414URI
  • https://doi.org/10.1080/02841860902862511DOI
  • https://lup.lub.lu.se/record/1392298URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119241196URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20418URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • DOI does not work: 10.1080/02841860902862511
  • HER2 is a treatment predictive factor for the effect of trastuzumab and associated with poor prognosis in breast cancer. The analysis of HER2 must be performed with good quality, with regard to both the immunohistochemical (IHC) and in situ hybridization (ISH) analysis.A tissue microarray (TMA) including 11 breast cancer samples was sent twice (once in 2005 and again in 2006) to 24 pathology departments in Sweden. A questionnaire was also sent to the departments in 2006.With IHC, all departments reported the same results (0/1+ vs. 2+ vs. 3 + ) for three (2005) and six samples (2006). The mean kappa-value increased from 0.67 to 0.77, indicating a good reproducibility at both occasions. With fluorescence-ISH (FISH), the 11 departments using this technique reported the same results (amplified vs. normal) for nine (2005) and ten samples (2006). The mean kappa-value showed very good reproducibility both 2005 and 2006 (0.92 and 0.96, respectively). Based on the answers from the participating departments, the questionnaire revealed that 31% of primary breast cancer diagnosed in 2006 (n = 5 043) were 2 + /3+. FISH analysis of 2+ confirmed 12% of the samples to be amplified. The corresponding figure for 3 + was 90%. In total, 14.3% of the samples were HER2 positive (2+ and amplified, or 3 + ).The results obtained in this study indicate that the reproducibility for HER2 analysis is good (IHC) and very good (FISH) between the pathology departments in Sweden using TMA-based tumor samples. In 2006, 14.3% of invasive breast cancers were HER2 positive.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Haglund, MonicaMalmö University Hospital (author)
  • Bendahl, Pär-OlaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital(Swepub:lu)onk-pbe (author)
  • Hatschek, ThomasKarolinska Institutet,Karolinska University Hospital (author)
  • Kolaric, AleksandraUniversity Hospital, Örebro (author)
  • Kovács, Anikó,1961Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Sahlgrens University Hospital(Swepub:gu)xkovan (author)
  • Olsson, AnnKarolinska University Hospital (author)
  • Olsson, HansÖstergötlands Läns Landsting,Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik(Swepub:liu)hanol61 (author)
  • Strand, CarinaLund University Hospital (author)
  • Fernö, MårtenLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital(Swepub:lu)onk-mfe (author)
  • Forsare, CarinaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-cst (author)
  • Kirurgi, LundSektion V (creator_code:org_t)

Related titles

  • In:Acta oncologica (Stockholm, Sweden): Informa UK Limited48:6, s. 860-61651-226X0284-186X

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