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Differential effect...
Differential effects of neurodegeneration biomarkers on subclinical cognitive decline
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Merluzzi, A. P. (author)
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Vogt, N. M. (author)
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Norton, D. (author)
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Jonaitis, E. (author)
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Clark, L. R. (author)
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Carlsson, C. M. (author)
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Johnson, S. C. (author)
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Asthana, S. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Bendlin, B. B. (author)
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(creator_code:org_t)
- 2019-04-12
- 2019
- English.
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In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. - : Wiley. - 2352-8737. ; 5, s. 129-138
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Abstract
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- Introduction: Neurodegeneration appears to be the biological mechanism most proximate to cognitive decline in Alzheimer's disease. We test whether t-tau and alternative biomarkers of neurodegeneration—neurogranin and neurofilament light protein (NFL)—add value in predicting subclinical cognitive decline. Methods: One hundred fifty cognitively unimpaired participants received a lumbar puncture for cerebrospinal fluid and at least two neuropsychological examinations (mean age at first visit = 59.3 ± 6.3 years; 67% female). Linear mixed effects models were used with cognitive composite scores as outcomes. Neurodegeneration interactions terms were the primary predictors of interest: age × NFL or age × neurogranin or age × t-tau. Models were compared using likelihood ratio tests. Results: Age × NFL accounted for a significant amount of variation in longitudinal change on preclinical Alzheimer's cognitive composite scores, memory composite scores, and learning scores, whereas age × neurogranin and age × t-tau did not. Discussion: These data suggest that NFL may be more sensitive to subclinical cognitive decline compared to other proposed biomarkers for neurodegeneration. © 2019
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Amyloid
- Biomarkers
- Cognition
- Cognitive decline
- Neurodegeneration
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Merluzzi, A. P.
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Vogt, N. M.
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Norton, D.
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Jonaitis, E.
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Clark, L. R.
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Carlsson, C. M.
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show more...
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Johnson, S. C.
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Asthana, S.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Bendlin, B. B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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University of Gothenburg