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- Vergallo, A. (author)
Plasma amyloid beta 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019-05-18
- Wiley,2019
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/281758
- https://gup.ub.gu.se/publication/281758URI
- https://doi.org/10.1016/j.jalz.2019.03.009DOI
Supplementary language notes
- Language:English
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- SwePubSwePub
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Notes
- Introduction: Blood-based biomarkers of pathophysiological brain amyloid beta (A beta) accumulation, particularly for preclinical target and large-scale interventions, are warranted to effectively enrich Alzheimer's disease clinical trials and management. Methods: We investigated whether plasma concentrations of the A beta(1-40)/A beta(1-42) ratio, assessed using the single-molecule array (Simoa) immunoassay, may predict brain A beta positron emission tomography status in a large-scale longitudinal monocentric cohort (N = 276) of older individuals with subjective memory complaints. We performed a hypothesis-driven investigation followed by a no-apriori hypothesis study using machine learning. Results: The receiver operating characteristic curve and machine learning showed a balanced accuracy of 76.5% and 81%, respectively, for the plasma A beta(1-40)/A beta(1-42) ratio. The accuracy is not affected by the apolipoprotein E (APOE) epsilon 4 allele, sex, or age. Discussion: Our results encourage an independent validation cohort study to confirm the indication that the plasma A beta(1-40)/A beta(1-42) ratio, assessed via Simoa, may improve future standard of care and clinical trial design. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Alzheimer's disease
- Plasma amyloid beta
- Simoa immunoassay
- Machine learning
- Subjective
- blood-based biomarkers
- decline
- progression
Added entries (persons, corporate bodies, meetings, titles ...)
- Megret, L. (author)
- Lista, S. (author)
- Cavedo, E. (author)
- Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
- Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
- Vanmechelen, E. (author)
- De Vos, A. (author)
- Habert, M. O. (author)
- Potier, M. C. (author)
- Dubois, B. (author)
- Neri, C. (author)
- Hampel, H. (author)
- Dubois, B. (author)
- Hampel, H. (author)
- Bakardjian, H. (author)
- Benali, H. (author)
- Colliot, O. (author)
- Marie-O, H. (author)
- Lamari, F. (author)
- Mochel, F. (author)
- Potier, M. C. (author)
- de Schotten, M. T. (author)
- Afshar, M. (author)
- Aguilar, L. F. (author)
- Akman-Anderson, L. (author)
- Arenas, J. (author)
- Avila, J. (author)
- Babiloni, C. (author)
- Baldacci, F. (author)
- Batrla, R. (author)
- Benda, N. (author)
- Black, K. L. (author)
- Bokde, A. L. W. (author)
- Bonuccelli, U. (author)
- Broich, K. (author)
- Cacciola, F. (author)
- Caraci, F. (author)
- Castrillo, J. (author)
- Cavedo, E. (author)
- Ceravolo, R. (author)
- Chiesa, P. A. (author)
- Corvol, J. C. (author)
- Cuello, A. C. (author)
- Cummings, J. L. (author)
- Depypere, H. (author)
- Dubois, B. (author)
- Duggento, A. (author)
- Emanuele, E. (author)
- Escott-Price, V. (author)
- Federoff, H. (author)
- Ferretti, M. T. (author)
- Fiandaca, M. (author)
- Frank, R. A. (author)
- Garaci, F. (author)
- Geerts, H. (author)
- Giorgi, F. S. (author)
- Goetzl, E. J. (author)
- Graziani, M. (author)
- Haberkamp, M. (author)
- Habert, M. O. (author)
- Hampel, H. (author)
- Herholz, K. (author)
- Hernandez, F. (author)
- Kapogiannis, D. (author)
- Karran, E. (author)
- Kiddle, S. J. (author)
- Kim, S. H. (author)
- Koronyo, Y. (author)
- Koronyo-Hamaoui, M. (author)
- Langevin, T. (author)
- Lehericy, S. (author)
- Lucia, A. (author)
- Lista, S. (author)
- Lorenceau, J. (author)
- Mango, D. (author)
- Mapstone, M. (author)
- Neri, C. (author)
- Nistico, R. (author)
- O'Bryant, S. E. (author)
- Palmero, G. (author)
- Perry, G. (author)
- Ritchie, C. (author)
- Rossi, S. (author)
- Saidi, A. (author)
- Santarnecchi, E. (author)
- Schneider, L. S. (author)
- Sporns, O. (author)
- Toschi, N. (author)
- Verdooner, S. R. (author)
- Vergallo, A. (author)
- Villain, N. (author)
- Welikovitch, L. A. (author)
- Woodcock, J. (author)
- Younesi, E. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
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- In:Alzheimers & Dementia: Wiley15:6, s. 764-7751552-52601552-5279
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- Vanmechelen, E.
- De Vos, A.
- Habert, M. O.
- Potier, M. C.
- Dubois, B.
- Neri, C.
- Hampel, H.
- Bakardjian, H.
- Benali, H.
- Colliot, O.
- Marie-O, H.
- Lamari, F.
- Mochel, F.
- de Schotten, M. ...
- Afshar, M.
- Aguilar, L. F.
- Akman-Anderson, ...
- Arenas, J.
- Avila, J.
- Babiloni, C.
- Baldacci, F.
- Batrla, R.
- Benda, N.
- Black, K. L.
- Bokde, A. L. W.
- Bonuccelli, U.
- Broich, K.
- Cacciola, F.
- Caraci, F.
- Castrillo, J.
- Ceravolo, R.
- Chiesa, P. A.
- Corvol, J. C.
- Cuello, A. C.
- Cummings, J. L.
- Depypere, H.
- Duggento, A.
- Emanuele, E.
- Escott-Price, V.
- Federoff, H.
- Ferretti, M. T.
- Fiandaca, M.
- Frank, R. A.
- Garaci, F.
- Geerts, H.
- Giorgi, F. S.
- Goetzl, E. J.
- Graziani, M.
- Haberkamp, M.
- Herholz, K.
- Hernandez, F.
- Kapogiannis, D.
- Karran, E.
- Kiddle, S. J.
- Kim, S. H.
- Koronyo, Y.
- Koronyo-Hamaoui, ...
- Langevin, T.
- Lehericy, S.
- Lucia, A.
- Lorenceau, J.
- Mango, D.
- Mapstone, M.
- Nistico, R.
- O'Bryant, S. E.
- Palmero, G.
- Perry, G.
- Ritchie, C.
- Rossi, S.
- Saidi, A.
- Santarnecchi, E.
- Schneider, L. S.
- Sporns, O.
- Toschi, N.
- Verdooner, S. R.
- Villain, N.
- Welikovitch, L. ...
- Woodcock, J.
- Younesi, E.
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- MEDICAL AND HEALTH SCIENCES
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- University of Gothenburg
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