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Health effects of e...
Health effects of exposure to diesel exhaust in diesel-powered trains
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Andersen, M. H. G. (författare)
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Frederiksen, M. (författare)
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Saber, A. T. (författare)
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Wils, R. S. (författare)
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Fonseca, A. S. (författare)
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Koponen, I. K. (författare)
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- Johannesson, Sandra, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Roursgaard, M. (författare)
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Loft, S. (författare)
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Moller, P. (författare)
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Vogel, U. (författare)
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(creator_code:org_t)
- 2019-06-11
- 2019
- Engelska.
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Ingår i: Particle and Fibre Toxicology. - : Springer Science and Business Media LLC. - 1743-8977. ; 16:21
- Relaterad länk:
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https://particleandf...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundShort-term controlled exposure to diesel exhaust (DE) in chamber studies have shown mixed results on lung and systemic effects. There is a paucity of studies on well-characterized real-life DE exposure in humans. In the present study, 29 healthy volunteers were exposed to DE while sitting as passengers in diesel-powered trains. Exposure in electric trains was used as control scenario. Each train scenario consisted of three consecutive days (6h/day) ending with biomarker samplings.ResultsCombustion-derived air pollutants were considerably higher in the passenger carriages of diesel trains compared with electric trains. The concentrations of black carbon and ultrafine particles were 8.5g/m(3) and 1.2-1.8x10(5) particles/cm(3) higher, respectively, in diesel as compared to electric trains. Net increases of NOx and NO2 concentrations were 317g/m(3) and 36g/m(3). Exposure to DE was associated with reduced lung function and increased levels of DNA strand breaks in peripheral blood mononuclear cells (PBMCs), whereas there were unaltered levels of oxidatively damaged DNA, soluble cell adhesion molecules, acute phase proteins in blood and urinary excretion of metabolites of polycyclic aromatic hydrocarbons. Also the microvascular function was unaltered. An increase in the low frequency of heart rate variability measures was observed, whereas time-domain measures were unaltered.ConclusionExposure to DE inside diesel-powered trains for 3days was associated with reduced lung function and systemic effects in terms of altered heart rate variability and increased levels of DNA strand breaks in PBMCs compared with electric trains.Trial registrationClinicalTrials.Gov (NCT03104387). Registered on March 23rd 2017
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Diesel exhaust
- Train exposure
- Lung function
- Cardiovascular function
- DNA damage
- Comet assay
- oxidatively damaged DNA
- short-term exposure
- lung-function
- peripheral-blood
- air-pollution
- inflammatory responses
- ultrafine
- particles
- particulate matter
- pulmonary exposure
- vascular function
- Toxicology
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- art (ämneskategori)
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Andersen, M. H. ...
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Frederiksen, M.
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Saber, A. T.
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Wils, R. S.
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Fonseca, A. S.
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Koponen, I. K.
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visa fler...
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Johannesson, San ...
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Roursgaard, M.
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Loft, S.
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Moller, P.
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Vogel, U.
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visa färre...
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