The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled study

• BackgroundInconsistent results for coffee consumption and bladder cancer (BC) risk have been shown in epidemiological studies. This research aims to increase the understanding of the association between coffee consumption and BC risk by bringing together worldwide case-control studies on this topic.MethodsData were collected from 13 case-control comprising of 5,911 cases and 16,172 controls. Pooled multivariate odds ratios (ORs), with corresponding 95% confidence intervals (CIs), were obtained using multilevel logistic regression models. Furthermore, linear dose-response relationships were examined using fractional polynomial models.ResultsNo association of BC risk was observed with coffee consumption among smokers. However, after adjustment for age, gender, and smoking, the risk was significantly increased for never smokers (ever vs. never coffee consumers: ORmodel2 1.30, 95% CI 1.06-1.59; heavy (>4 cups/day) coffee consumers vs. never coffee consumers: ORmodel2 1.52, 95% CI 1.18-1.97, p trend=0.23). In addition, dose-response analyses, in both the overall population and among never smokers, also showed a significant increased BC risk for coffee consumption of more than four cups per day. Among smokers, a significant increased BC risk was shown only after consumption of more than six cups per day.ConclusionThis research suggests that positive associations between coffee consumption and BC among never smokers but not smokers.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Bladder cancer

Coffee consumption

Smoking

Dose-response analyses

Population-attributable risk

tobacco smoking

risk-factors

recall bias

tea consumption

fluid

intake

caffeine

drinking

occupation

mortality

alcohol

Oncology

Public

Environmental & Occupational Health

ortvliet ej

1992

european journal of clinical nutrition

v46

ps9

eineck g

1990

international journal of cancer

v45

p1006

ouinard e

1995

journal of clinical epidemiology

v48

p245

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)