WFRF:(Ahlin C.)
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- Ahlin, Sofie,1985Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (författare)
Bile acid changes after metabolic surgery are linked to improvement in insulin sensitivity
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
- 2019-06-19
- Oxford University Press (OUP),2019
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/282289
- https://gup.ub.gu.se/publication/282289URI
- https://doi.org/10.1002/bjs.11208DOI
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- Språk:engelska
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- Background: Metabolic surgery is associated with a prompt improvement in insulin resistance, although the mechanism of action remains unknown. The literature on bile acid changes after metabolic surgery is conflicting, and insulin sensitivity is generally assessed by indirect methods. The aim of this study was to investigate the relationship between improvement in insulin sensitivity and concentration of circulating bile acids after biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB). Methods: This was a prospective observational study of nine patients who underwent BPD and six who had RYGB. Inclusion criteria for participation were a BMI in excess of 40 kg/m(2), no previous diagnosis of type 2 diabetes and willingness to participate. Exclusion criteria were major endocrine diseases, malignancies and liver cirrhosis. Follow-up visits were carried out after a mean(s.d.) of 185.3(72.9) days. Fasting plasma bile acids were assessed by ultra-high-performance liquid chromatography coupled with a triple quadrupole mass spectrometer, and insulin sensitivity was measured by means of a hyperinsulinaemic-euglycaemic clamp. Results: A significant increase in all bile acids, as well as an amelioration of insulin sensitivity, was observed after metabolic surgery. An increase in conjugated secondary bile acids was significantly associated with an increase in insulin sensitivity. Only the increase in glycodeoxycholic acid was significantly associated with an increase in insulin sensitivity in analysis of individual conjugated secondary bile acids. Conclusion: Glycodeoxycholic acid might drive the improved insulin sensitivity after metabolic surgery.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- y gastric bypass
- weight-loss
- bariatric surgery
- nuclear receptor
- improved glucose
- identification
- resistance
- increases
- ligands
- fxr
- Surgery
- fronzo ra
- 1979
- american journal of physiology
- v237
- pe214
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Cefalu, C. (författare)
- Bondia-Pons, I. (författare)
- Capristo, E. (författare)
- Marini, L. (författare)
- Gastaldelli, A. (författare)
- Mingrone, G. (författare)
- Nolan, J. J. (författare)
- Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:British Journal of Surgery: Oxford University Press (OUP)106:90007-13231365-2168
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- British Journal of Surgery (Sök värdpublikationen i LIBRIS)
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- Ahlin, Sofie, 19 ...
- Cefalu, C.
- Bondia-Pons, I.
- Capristo, E.
- Marini, L.
- Gastaldelli, A.
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- Mingrone, G.
- Nolan, J. J.
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- MEDICIN OCH HÄLSOVETENSKAP
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