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A new perspective f...
A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies
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- Perani, Daniela (author)
- Vita-Salute San Raffaele University,San Raffaele Hospital
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- Iaccarino, Leonardo (author)
- San Raffaele Hospital,Vita-Salute San Raffaele University
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- Lammertsma, Adriaan A. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Windhorst, Albert D. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Edison, Paul (author)
- Imperial College London
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- Boellaard, Ronald (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Nordberg, Agneta (author)
- Karolinska Institutet,Karolinska Institute
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- Jacobs, Andreas H. (author)
- Johanniter Krankenhaus,University of Münster
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(creator_code:org_t)
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- 2019-06-20
- 2019
- English.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260. ; 15:8, s. 1081-1103
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Abstract
Subject headings
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- Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Amyloid
- Neuroinflammation
- PET molecular imaging
- Protheinopathies
- Radiotracers
- Tau
Publication and Content Type
- art (subject category)
- ref (subject category)
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