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- Elvstam, O.Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Klinisk infektionsmedicin,Clinical Microbiology, Malmö,Lund University Research Groups,Clinical infection medicine (författare)
Is low-level HIV-1 viraemia associated with elevated levels of markers of immune activation, coagulation and cardiovascular disease?
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
- 2019-05-30
- Wiley,2019
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/282532
- https://gup.ub.gu.se/publication/282532URI
- https://doi.org/10.1111/hiv.12756DOI
- https://lup.lub.lu.se/record/27c9b1cb-d6a3-4e61-8547-4736273c32d2URI
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- Språk:engelska
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- Objectives: The clinical significance of low-level viraemia (LLV) during antiretroviral therapy (ART) is debated. We retrospectively investigated longitudinal levels of plasma markers associated with inflammation, altered coagulation and cardiovascular disease in Swedish HIV-positive adults in relation to LLV or permanent virological suppression during long-term ART. Methods: Plasma levels of C-reactive protein (CRP), D-dimer, vascular cell adhesion molecule 1 (VCAM-1), suppression of tumorigenicity 2 (ST2), growth differentiation factor 15 (GDF-15), soluble CD14 (sCD14), soluble CD163 (sCD163), interferon-γ-induced protein 10 (IP-10) and β-2-microglobulin were measured in 34 individuals with LLV (viral load 50–999 HIV-1 RNA copies/mL) and in matched controls with persistent virological suppression. Biomarker levels were analysed in samples obtained during episodes of LLV and follow-up samples obtained 1year later (with similar timing for controls). All biomarkers were analysed using an independent sample t-test and analysis of covariance (ANCOVA) after logarithmic transformation. Log-rank analysis was applied for markers with concentration values out of range. Results: Compared with controls, patients with LLV had significantly higher levels of GDF-15 [geometric mean 3416 (95% confidence interval (CI) 804–14516) pg/mL versus 2002 (95% CI 355–11295) pg/mL in controls; P=0.026] and D-dimer [mean 1114 (95% CI 125–9917) ng/mL versus 756 (95% CI 157–3626) ng/mL; P=0.038] after adjustment for age, CD4 count nadir and type of ART. In the unadjusted t-test, only GDF-15 was significantly higher and in the log-rank test, both GDF-15 and D-dimer were significantly elevated. No significant differences were observed for the other biomarkers analysed. Conclusions: Although levels of inflammation markers were similar in ART recipients with and without LLV, persons with LLV had significantly higher levels of GDF-15 and D-dimer. These findings suggest a potential link between LLV and cardiovascular outcomes. © 2019 British HIV Association
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
- cardiovascular disease
- coagulation
- HIV
- inflammation
- low-level viraemia
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Medstrand, P.Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Klinisk virologi, Malmö,Clinical Microbiology, Malmö,Lund University Research Groups,Clinical Virology, Malmö(Swepub:lu)mmb-pme (författare)
- Jansson, M.Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,HIV-1 and HIV-2 host interactions,Lund University Research Groups(Swepub:lu)mmb-mj0 (författare)
- Isberg, P. E.Lund University,Lunds universitet,Statistiska institutionen,Ekonomihögskolan,Department of Statistics,Lund University School of Economics and Management, LUSEM(Swepub:lu)stat-pis (författare)
- Gisslén, Magnus,1962University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Sahlgrenska University Hospital(Swepub:gu)xgissm (författare)
- Björkman, P.Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Klinisk infektionsmedicin,Clinical Microbiology, Malmö,Lund University Research Groups,Clinical infection medicine(Swepub:lu)inf-pbj (författare)
- Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:HIV Medicine: Wiley20:9, s. 571-5801464-26621468-1293
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- Elvstam, O.
- Medstrand, P.
- Jansson, M.
- Isberg, P. E.
- Gisslén, Magnus, ...
- Björkman, P.
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- MEDICIN OCH HÄLSOVETENSKAP
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- HIV Medicine
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- Göteborgs universitet
- Lunds universitet
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