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Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis

Efe, C. (författare)
Department of Gastroenterology, Gazi Yaşargil Education and Research Hospital, Diyarbakir, Turkey,Gazi Yasargil Educ & Res Hosp, Dept Gastroenterol, Diyarbakir, Turkey
Tascilar, K. (författare)
Department of Rheumatology, Istanbul Okmeydani Education and Research Hospital, Istanbul, Turkey,Istanbul Okmeydani Educ & Res Hosp, Dept Rheumatol, Istanbul, Turkey
Henriksson, Ida, 1980- (författare)
Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Fac Med & Hlth, Dept Gastroenterol, Orebro, Sweden
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Lytvyak, E. (författare)
Division of Gastroenterology and Liver Unit, University of Alberta, Alberta, Canada,Univ Alberta, Div Gastroenterol, Edmonton, AB, Canada;Univ Alberta, Liver Unit, Edmonton, AB, Canada
Alalkim, F. (författare)
Division of Gastroenterology, University of British Columbia and Vancouver General Hospital, Vancouver, Canada,Univ British Columbia, Div Gastroenterol, Vancouver, BC, Canada;Vancouver Gen Hosp, Vancouver, BC, Canada
Trivedi, H. (författare)
Division of GI and Hepatology, Beth Israel Medical Center, Harvard Medical School, Boston MA, USA,Harvard Med Sch, Beth Israel Med Ctr, Div GI & Hepatol, Boston, MA 02115 USA,Beth Israel Deaconess Medical Center
Eren, F. (författare)
Department of Gastroenterology, Medical Faculty, Uludag University, Bursa, Turkey,Uludag Univ, Med Fac, Dept Gastroenterol, Bursa, Turkey
Eliasson, J. (författare)
Department of Hepatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Rigshosp, Dept Hepatol, Copenhagen, Denmark
Beretta-Piccoli, B. T. (författare)
Department of Internal Medicine, Epatocentro Ticino, Lugano, Switzerland,Section of Hepatology, Clinic for Gastroenterology, University Clinic Leipzig, Leipzig, Germany,Epatoctr Ticino, Dept Internal Med, Lugano, Switzerland,Univ Clin Leipzig, Sect Hepatol, Clin Gastroenterol, Leipzig, Germany,University Hospital Leipzig
Fischer, J. (författare)
Section of Hepatology, Clinic for Gastroenterology, University Clinic Leipzig, Leipzig, Germany,Univ Clin Leipzig, Sect Hepatol, Clin Gastroenterol, Leipzig, Germany,University Hospital Leipzig
Caliskan, A. R. (författare)
Department of Gastroenterology, Inönü University School of Medicine, Malatya, Turkey,Inonu Univ, Sch Med, Dept Gastroenterol, Malatya, Turkey
Chayanupatkul, M. (författare)
Division of Liver Diseases, the Mount Sinai Medical Center, New York NY, USA; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand,Mt Sinai Med Ctr, Div Liver Dis, New York, NY 10029 USA;Chulalongkorn Univ, Fac Med, Bangkok, Thailand
Coppo, C. (författare)
Center for the Study and Treatment of Autoimmune Diseases of the Liver and Biliary System, University of Bologna, Bologna, Italy,Univ Bologna, Ctr Study & Treatment Autoimmune Dis Liver & Bili, Bologna, Italy
Ytting, H. (författare)
Department of Hepatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Rigshosp, Dept Hepatol, Copenhagen, Denmark
Purnak, T. (författare)
Department of Gastroenterology, Hacettepe University, Ankara, Turkey,Hacettepe Univ, Dept Gastroenterol, Ankara, Turkey
Muratori, L. (författare)
Center for the Study and Treatment of Autoimmune Diseases of the Liver and Biliary System, University of Bologna, Bologna, Italy,Univ Bologna, Ctr Study & Treatment Autoimmune Dis Liver & Bili, Bologna, Italy
Werner, Mårten (författare)
Umeå University,Umeå universitet,Avdelningen för medicin,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden
Muratori, P. (författare)
Center for the Study and Treatment of Autoimmune Diseases of the Liver and Biliary System, University of Bologna, Bologna, Italy,Univ Bologna, Ctr Study & Treatment Autoimmune Dis Liver & Bili, Bologna, Italy
Rorsman, Fredrik, Docent, 1960- (författare)
Uppsala universitet,Gastroenterologi/hepatologi,Uppsala University Hospital
Önnerhag, Kristina (författare)
Department of Gastroenterology and Hepatology, Skåne University Hospital, Malmö, Sweden,Skane Univ Hosp, Dept Gastroenterol & Hepatol, Malmo, Sweden
Gunsar, F. (författare)
Department of Gastroenterology, Ege University, Bornova, Izmir, Turkey,Ege Univ, Dept Gastroenterol, Izmir, Turkey
Nilsson, Emma (författare)
Lund University,Lunds universitet,Gastro,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
Heurgue-Berlot, A. (författare)
Department of Hepato-Gastroenterology, CHU Reims, Reims, France,CHU Reims, Dept Hepatogastroenterol, Reims, France,Centre Hospitalier Universitaire Reims
Guzelbulut, F. (författare)
Department of Gastroenterology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey,Haydarpasa Numune Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey,Istanbul Haydarpasa Numune Training and Research Hospital
Demir, N. (författare)
Department of Gastroenterology, Gazi Yaşargil Education and Research Hospital, Diyarbakir, Turkey,Gazi Yasargil Educ & Res Hosp, Dept Gastroenterol, Diyarbakir, Turkey
Gonen, C. (författare)
Department of Gastroenterology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey,Haydarpasa Numune Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey,Istanbul Haydarpasa Numune Training and Research Hospital
Semela, D. (författare)
Division of Gastroenterology and Hepatology, Kantonsspital St. Gallen, St. Gallen, Switzerland,Kantonsspital St Gallen, Div Gastroenterol & Hepatol, St Gallen, Switzerland
Aladag, M. (författare)
Department of Gastroenterology, Inönü University School of Medicine, Malatya, Turkey,Inonu Univ, Sch Med, Dept Gastroenterol, Malatya, Turkey
Kiyici, M. (författare)
Department of Gastroenterology, Medical Faculty, Uludag University, Bursa, Turkey,Uludag Univ, Med Fac, Dept Gastroenterol, Bursa, Turkey
Schiano, T. (författare)
Division of Liver Diseases, the Mount Sinai Medical Center, New York NY, USA,Mt Sinai Med Ctr, Div Liver Dis, New York, NY 10029 USA
Montano-Loza, A. (författare)
Division of Gastroenterology and Liver Unit, University of Alberta, Alberta, Canada,Univ Alberta, Div Gastroenterol, Edmonton, AB, Canada;Univ Alberta, Liver Unit, Edmonton, AB, Canada
Berg, T. (författare)
Ozaslan, E. (författare)
Department of Gastroenterology, Numune Research and Education Hospital, Ankara, Turkey,Numune Res & Educ Hosp, Dept Gastroenterol, Ankara, Turkey
Yoshida, E. (författare)
Division of Gastroenterology, University of British Columbia and Vancouver General Hospital, Vancouver, Canada,Univ British Columbia, Div Gastroenterol, Vancouver, BC, Canada;Vancouver Gen Hosp, Vancouver, BC, Canada
Bonder, A. (författare)
Division of GI and Hepatology, Beth Israel Medical Center, Harvard Medical School, Boston MA, USA,Harvard Med Sch, Beth Israel Med Ctr, Div GI & Hepatol, Boston, MA 02115 USA,Beth Israel Deaconess Medical Center
Marschall, Hanns-Ulrich (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden
Wahlin, S. (författare)
Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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 (creator_code:org_t)
2019-06-19
2019
Engelska.
Ingår i: American Journal of Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 0002-9270 .- 1572-0241. ; 114:7, s. 1101-1108
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • INTRODUCTION: Risk stratification based on biochemical variables is a useful tool for monitoring ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC). Several UDCA response criteria and scoring systems have been proposed for risk prediction in PBC, but these have not been validated in large external cohorts. METHODS: We performed a study on data of 1746 UDCA-treated patients with PBC from 25 centers in Europe, United States, and Canada. The prognostic performance of the risk scoring systems (GLOBE and UK-PBC) and the UDCA response criteria (Barcelona, Paris I, Paris II, Rotterdam, and Toronto) were evaluated. We regarded cirrhosis-related complications (ascites, variceal bleeding, and/or hepatic encephalopathy) as clinical end points. RESULTS: A total of 171 patients reached a clinical end point during a median 7 years (range 1-16 years) of follow-up. The 5-, 10- and 15-year adverse outcome-free survivals were 95%, 85%, and 77%. The GLOBE and UK-PBC scores predicted cirrhosis-related complications better than the UDCA response criteria. The hazard ratio (HR) for a 1 standard deviation increase was HR 5.05 (95% confidence interval (CI): 4.43-5.74, P < 0.001) for the GLOBE score and HR 3.39 (95% CI: 3.10-3.72, P < 0.001) for the UK-PBC score. Overall, the GLOBE and UK-PBC risk scores showed similar and excellent prognostic performance (C-statistic, 0.93; 95% CI: 0.91%-95% vs 0.94; 95% CI: 0.91%-0.96%). DISCUSSION: In our international, multicenter PBC cohort, the GLOBE and UK-PBC risk scoring systems were good predictors of future cirrhosis-related complications.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

placebo-controlled trial
biochemical response
histological
progression
cirrhosis
bezafibrate
prediction
prognosis
survival
outcomes
globe
Gastroenterology & Hepatology

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