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  • Efe, C.Department of Gastroenterology, Gazi Yaşargil Education and Research Hospital, Diyarbakir, Turkey,Gazi Yasargil Educ & Res Hosp, Dept Gastroenterol, Diyarbakir, Turkey (författare)

Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-06-19
  • Ovid Technologies (Wolters Kluwer Health),2019

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/282590
  • https://gup.ub.gu.se/publication/282590URI
  • https://doi.org/10.14309/ajg.0000000000000290DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-75733URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162014URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-391961URI
  • https://lup.lub.lu.se/record/0135bb0b-e896-41f7-ae34-1300c7fce1e4URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141417430URI

Kompletterande språkuppgifter

  • Språk:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • INTRODUCTION: Risk stratification based on biochemical variables is a useful tool for monitoring ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC). Several UDCA response criteria and scoring systems have been proposed for risk prediction in PBC, but these have not been validated in large external cohorts. METHODS: We performed a study on data of 1746 UDCA-treated patients with PBC from 25 centers in Europe, United States, and Canada. The prognostic performance of the risk scoring systems (GLOBE and UK-PBC) and the UDCA response criteria (Barcelona, Paris I, Paris II, Rotterdam, and Toronto) were evaluated. We regarded cirrhosis-related complications (ascites, variceal bleeding, and/or hepatic encephalopathy) as clinical end points. RESULTS: A total of 171 patients reached a clinical end point during a median 7 years (range 1-16 years) of follow-up. The 5-, 10- and 15-year adverse outcome-free survivals were 95%, 85%, and 77%. The GLOBE and UK-PBC scores predicted cirrhosis-related complications better than the UDCA response criteria. The hazard ratio (HR) for a 1 standard deviation increase was HR 5.05 (95% confidence interval (CI): 4.43-5.74, P < 0.001) for the GLOBE score and HR 3.39 (95% CI: 3.10-3.72, P < 0.001) for the UK-PBC score. Overall, the GLOBE and UK-PBC risk scores showed similar and excellent prognostic performance (C-statistic, 0.93; 95% CI: 0.91%-95% vs 0.94; 95% CI: 0.91%-0.96%). DISCUSSION: In our international, multicenter PBC cohort, the GLOBE and UK-PBC risk scoring systems were good predictors of future cirrhosis-related complications.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Tascilar, K.Department of Rheumatology, Istanbul Okmeydani Education and Research Hospital, Istanbul, Turkey,Istanbul Okmeydani Educ & Res Hosp, Dept Rheumatol, Istanbul, Turkey (författare)
  • Henriksson, Ida,1980-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Fac Med & Hlth, Dept Gastroenterol, Orebro, Sweden(Swepub:oru)iahn (författare)
  • Lytvyak, E.Division of Gastroenterology and Liver Unit, University of Alberta, Alberta, Canada,Univ Alberta, Div Gastroenterol, Edmonton, AB, Canada;Univ Alberta, Liver Unit, Edmonton, AB, Canada (författare)
  • Alalkim, F.Division of Gastroenterology, University of British Columbia and Vancouver General Hospital, Vancouver, Canada,Univ British Columbia, Div Gastroenterol, Vancouver, BC, Canada;Vancouver Gen Hosp, Vancouver, BC, Canada (författare)
  • Trivedi, H.Division of GI and Hepatology, Beth Israel Medical Center, Harvard Medical School, Boston MA, USA,Harvard Med Sch, Beth Israel Med Ctr, Div GI & Hepatol, Boston, MA 02115 USA,Beth Israel Deaconess Medical Center (författare)
  • Eren, F.Department of Gastroenterology, Medical Faculty, Uludag University, Bursa, Turkey,Uludag Univ, Med Fac, Dept Gastroenterol, Bursa, Turkey (författare)
  • Eliasson, J.Department of Hepatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Rigshosp, Dept Hepatol, Copenhagen, Denmark (författare)
  • Beretta-Piccoli, B. T.Department of Internal Medicine, Epatocentro Ticino, Lugano, Switzerland,Section of Hepatology, Clinic for Gastroenterology, University Clinic Leipzig, Leipzig, Germany,Epatoctr Ticino, Dept Internal Med, Lugano, Switzerland,Univ Clin Leipzig, Sect Hepatol, Clin Gastroenterol, Leipzig, Germany,University Hospital Leipzig (författare)
  • Fischer, J.Section of Hepatology, Clinic for Gastroenterology, University Clinic Leipzig, Leipzig, Germany,Univ Clin Leipzig, Sect Hepatol, Clin Gastroenterol, Leipzig, Germany,University Hospital Leipzig (författare)
  • Caliskan, A. R.Department of Gastroenterology, Inönü University School of Medicine, Malatya, Turkey,Inonu Univ, Sch Med, Dept Gastroenterol, Malatya, Turkey (författare)
  • Chayanupatkul, M.Division of Liver Diseases, the Mount Sinai Medical Center, New York NY, USA; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand,Mt Sinai Med Ctr, Div Liver Dis, New York, NY 10029 USA;Chulalongkorn Univ, Fac Med, Bangkok, Thailand (författare)
  • Coppo, C.Center for the Study and Treatment of Autoimmune Diseases of the Liver and Biliary System, University of Bologna, Bologna, Italy,Univ Bologna, Ctr Study & Treatment Autoimmune Dis Liver & Bili, Bologna, Italy (författare)
  • Ytting, H.Department of Hepatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Rigshosp, Dept Hepatol, Copenhagen, Denmark (författare)
  • Purnak, T.Department of Gastroenterology, Hacettepe University, Ankara, Turkey,Hacettepe Univ, Dept Gastroenterol, Ankara, Turkey (författare)
  • Muratori, L.Center for the Study and Treatment of Autoimmune Diseases of the Liver and Biliary System, University of Bologna, Bologna, Italy,Univ Bologna, Ctr Study & Treatment Autoimmune Dis Liver & Bili, Bologna, Italy (författare)
  • Werner, MårtenUmeå University,Umeå universitet,Avdelningen för medicin,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden(Swepub:umu)manwer04 (författare)
  • Muratori, P.Center for the Study and Treatment of Autoimmune Diseases of the Liver and Biliary System, University of Bologna, Bologna, Italy,Univ Bologna, Ctr Study & Treatment Autoimmune Dis Liver & Bili, Bologna, Italy (författare)
  • Rorsman, Fredrik,Docent,1960-Uppsala universitet,Gastroenterologi/hepatologi,Uppsala University Hospital(Swepub:uu)fredrikr (författare)
  • Önnerhag, KristinaDepartment of Gastroenterology and Hepatology, Skåne University Hospital, Malmö, Sweden,Skane Univ Hosp, Dept Gastroenterol & Hepatol, Malmo, Sweden(Swepub:lu)med-kso (författare)
  • Gunsar, F.Department of Gastroenterology, Ege University, Bornova, Izmir, Turkey,Ege Univ, Dept Gastroenterol, Izmir, Turkey (författare)
  • Nilsson, EmmaLund University,Lunds universitet,Gastro,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-en0 (författare)
  • Heurgue-Berlot, A.Department of Hepato-Gastroenterology, CHU Reims, Reims, France,CHU Reims, Dept Hepatogastroenterol, Reims, France,Centre Hospitalier Universitaire Reims (författare)
  • Guzelbulut, F.Department of Gastroenterology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey,Haydarpasa Numune Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey,Istanbul Haydarpasa Numune Training and Research Hospital (författare)
  • Demir, N.Department of Gastroenterology, Gazi Yaşargil Education and Research Hospital, Diyarbakir, Turkey,Gazi Yasargil Educ & Res Hosp, Dept Gastroenterol, Diyarbakir, Turkey (författare)
  • Gonen, C.Department of Gastroenterology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey,Haydarpasa Numune Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey,Istanbul Haydarpasa Numune Training and Research Hospital (författare)
  • Semela, D.Division of Gastroenterology and Hepatology, Kantonsspital St. Gallen, St. Gallen, Switzerland,Kantonsspital St Gallen, Div Gastroenterol & Hepatol, St Gallen, Switzerland (författare)
  • Aladag, M.Department of Gastroenterology, Inönü University School of Medicine, Malatya, Turkey,Inonu Univ, Sch Med, Dept Gastroenterol, Malatya, Turkey (författare)
  • Kiyici, M.Department of Gastroenterology, Medical Faculty, Uludag University, Bursa, Turkey,Uludag Univ, Med Fac, Dept Gastroenterol, Bursa, Turkey (författare)
  • Schiano, T.Division of Liver Diseases, the Mount Sinai Medical Center, New York NY, USA,Mt Sinai Med Ctr, Div Liver Dis, New York, NY 10029 USA (författare)
  • Montano-Loza, A.Division of Gastroenterology and Liver Unit, University of Alberta, Alberta, Canada,Univ Alberta, Div Gastroenterol, Edmonton, AB, Canada;Univ Alberta, Liver Unit, Edmonton, AB, Canada (författare)
  • Berg, T. (författare)
  • Ozaslan, E.Department of Gastroenterology, Numune Research and Education Hospital, Ankara, Turkey,Numune Res & Educ Hosp, Dept Gastroenterol, Ankara, Turkey (författare)
  • Yoshida, E.Division of Gastroenterology, University of British Columbia and Vancouver General Hospital, Vancouver, Canada,Univ British Columbia, Div Gastroenterol, Vancouver, BC, Canada;Vancouver Gen Hosp, Vancouver, BC, Canada (författare)
  • Bonder, A.Division of GI and Hepatology, Beth Israel Medical Center, Harvard Medical School, Boston MA, USA,Harvard Med Sch, Beth Israel Med Ctr, Div GI & Hepatol, Boston, MA 02115 USA,Beth Israel Deaconess Medical Center (författare)
  • Marschall, Hanns-Ulrich,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden(Swepub:gu)xmarsh (författare)
  • Wahlin, S.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
  • Department of Gastroenterology, Gazi Yaşargil Education and Research Hospital, Diyarbakir, TurkeyGazi Yasargil Educ & Res Hosp, Dept Gastroenterol, Diyarbakir, Turkey (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Gastroenterology: Ovid Technologies (Wolters Kluwer Health)114:7, s. 1101-11080002-92701572-0241

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