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Serum tau fragments...
Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest
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- Grand, J. (author)
- Copenhagen University Hospital
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- Kjaergaard, J. (author)
- Copenhagen University Hospital
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- Nielsen, Niklas (author)
- Helsingborg Hospital
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- Friberg, Hans (author)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital
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- Cronberg, Tobias (author)
- Sanos Clinic
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- Bro-Jeppesen, J. (author)
- Copenhagen University Hospital
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- Karsdal, M. A. (author)
- Nordic Bioscience AS
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- Nielsen, H. B. (author)
- Sanos Clinic
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- Frydland, M. (author)
- Copenhagen University Hospital
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- Henriksen, K. (author)
- Nordic Bioscience AS
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- Mattsson, Niklas (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Zetterberg, Henrik, 1973 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Sahlgrenska University Hospital,University College London
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- Hassager, C. (author)
- Copenhagen University Hospital
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: Biomarkers. - 1354-750X. ; 24:6, s. 584-591
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 h after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 h after OHCA. The primary endpoint was neurological outcome. Results: Median (quartile 1–quartile 3) tau-A (ng/ml) values were 58 (43–71) versus 51 (43–67), 72 (57–84) versus 71 (59–82) and 76 (61–92) versus 75 (64–89) for good versus unfavourable outcome at 24, 48 and 72 h, respectively (pgroup = 0.95). Median tau C (ng/ml) values were 38 (29–50) versus 36 (29–49), 49 (38–58) versus 48 (33–59) and 48 (39–59) versus 48 (36–62) (pgroup = 0.95). Tau-A and tau-C did not predict neurological outcome (area under the receiver-operating curve at 48 h; tau-A: 0.51 and tau-C: 0.51). Conclusions: Serum levels of tau fragments were unable to predict neurological outcome after OHCA. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- neurological outcome
- out-of-hospital cardiac arrest
- prognosis
- Serum biomarkers
- tau fragments
Publication and Content Type
- ref (subject category)
- art (subject category)
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Biomarkers
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- By the author/editor
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Grand, J.
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Kjaergaard, J.
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Nielsen, Niklas
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Friberg, Hans
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Cronberg, Tobias
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Bro-Jeppesen, J.
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show more...
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Karsdal, M. A.
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Nielsen, H. B.
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Frydland, M.
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Henriksen, K.
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Mattsson, Niklas
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Zetterberg, Henr ...
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Hassager, C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Biomarkers
- By the university
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University of Gothenburg
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Lund University