Homeostatic Chemokines and Prognosisin Patients With Acute Coronary Syndromes.

Caidahl, Kenneth,1949Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)

The chemokines CCL19 and CCL21 are up-regulated in atherosclerotic disease and heart failure, and increased circulating levels are found in unstable versus stable coronary artery disease.The purpose of this study was to evaluate the prognostic value of CCL19 and CCL21 in acute coronary syndrome (ACS).CCL19 and CCL21 levels were analyzed in serum obtained from ACS patients (n=1,146) on the first morning after hospital admission. Adjustments were made for GRACE (Global Registry of Acute Coronary Events) score, left ventricular ejection fraction, pro-B-type natriuretic peptide, troponin I, and C-reactive protein levels.The major findings were: 1) those having fourth quartile levels of CCL21 on admission of ACS had a significantly higher long-term (median 98months) risk of major adverse cardiovascular events (MACE) and myocardial infarction in fully adjusted multivariable models; 2) high CCL21 levels at admission were also independently associated with MACE and cardiovascular mortality during short-time (3months) follow-up; and 3) high CCL19 levels at admission were associated with the development of heart failure.CCL21 levels are independently associated with outcome after ACS and should be further investigated as a promising biomarker in these patients.

Hartford, Marianne,1944Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xhartm (author)
Ravn-Fischer, Annica,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xravan (author)
Lorentzen, Erik,1974Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Core Facilities, Bioinformatics(Swepub:gu)xjacer (author)
Yndestad, Arne (author)
Karlsson, Thomas,1956Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri,Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics(Swepub:gu)xkarth (author)
Aukrust, Pål (author)
Ueland, Thor (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

In:Journal of the American College of Cardiology: Elsevier BV74:6, s. 774-7821558-35970735-1097

By the author/editor: Caidahl, Kenneth ...; Hartford, Marian ...; Ravn-Fischer, An ...; Lorentzen, Erik, ...; Yndestad, Arne; Karlsson, Thomas ...; show more...; Aukrust, Pål; Ueland, Thor; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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