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Genome-wide associa...
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
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Watson, H. J. (author)
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Yilmaz, Z. (author)
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- Thorntont, L. M. (author)
- Karolinska Institutet
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show more...
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- Hubel, C. (author)
- Karolinska Institutet
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Coleman, J. R. I. (author)
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Gaspar, H. A. (author)
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- Bryois, J. (author)
- Karolinska Institutet
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- Adan, Roger A. H. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Leppa, V. M. (author)
- Karolinska Institutet
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- Mattheisen, M. (author)
- Karolinska Institutet
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Medland, S. E. (author)
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Ripke, S. (author)
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- Yao, S. Y. (author)
- Karolinska Institutet
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Giusti-Rodriguez, P. (author)
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Hanscombe, K. B. (author)
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- Purves, K. L. (author)
- Karolinska Institutet
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- Adan, Roger A. H. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Alfredsson, L. (author)
- Karolinska Institutet
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Ando, T. (author)
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Andreassen, O. A. (author)
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Baker, J. H. (author)
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Berrettini, W. H. (author)
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Boehm, I. (author)
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Boni, C. (author)
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Perica, V. B. (author)
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Buehren, K. (author)
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Burghardt, R. (author)
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Cassina, M. (author)
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Cichon, S. (author)
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Clementi, M. (author)
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Cone, R. D. (author)
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Courtet, P. (author)
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Crow, S. (author)
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Crowley, J. J. (author)
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Danner, U. N. (author)
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Davis, O. S. P. (author)
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de Zwaan, M. (author)
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Dedoussis, G. (author)
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Degortes, D. (author)
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DeSocio, J. E. (author)
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Dick, D. M. (author)
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Dikeos, D. (author)
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Dina, C. (author)
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Dmitrzak-Weglarz, M. (author)
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Docampo, E. (author)
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Duncan, L. E. (author)
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Egberts, K. (author)
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Ehrlich, S. (author)
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Escaramis, G. (author)
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Eskos, T. (author)
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Estivill, X. (author)
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Farmer, A. (author)
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Favaro, A. (author)
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Fernandez-Aranda, F. (author)
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Fichter, M. M. (author)
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Fischer, K. (author)
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Focker, M. (author)
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Foretova, L. (author)
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Forstner, A. J. (author)
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Forzan, M. (author)
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Franklin, C. S. (author)
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Gallinger, S. (author)
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Giegling, I. (author)
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Giuranna, J. (author)
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Gonidakis, F. (author)
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Gorwood, P. (author)
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Mayora, M. G. (author)
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Guillaume, S. (author)
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Guo, Y. R. (author)
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Hakonarson, H. (author)
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Hatzikotoulas, K. (author)
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Hauser, J. (author)
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Hebebrand, J. (author)
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Helder, S. G. (author)
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Herms, S. (author)
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Herpertz-Dahlmann, B. (author)
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Herzog, W. (author)
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Huckins, L. M. (author)
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Hudson, J. I. (author)
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Imgart, H. (author)
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Inoko, H. (author)
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Janout, V. (author)
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Jimenez-Murcia, S. (author)
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Julia, A. (author)
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Kalsi, G. (author)
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Kaminska, D. (author)
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Kaprio, J. (author)
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Karhunen, L. (author)
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Karwautz, A. (author)
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Kas, M. J. H. (author)
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Kennedy, J. L. (author)
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Keski-Rahkonen, A. (author)
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Kiezebrink, K. (author)
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Kim, Y. R. (author)
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Klareskog, L. (author)
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Klump, K. L. (author)
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Knudsen, G. P. S. (author)
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La Via, M. C. (author)
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Le Hellard, S. (author)
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Levitan, R. D. (author)
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Li, D. (author)
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- Lilenfeld, L. (author)
- Karolinska Institutet
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Lin, B. D. (author)
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Lissowska, J. (author)
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Luykx, J. (author)
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Magistretti, P. J. (author)
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Maj, M. (author)
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Mannik, K. (author)
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Marsal, S. (author)
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Marshall, C. R. (author)
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Mattingsdal, M. (author)
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McDevitt, S. (author)
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McGuffin, P. (author)
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Metspalu, A. (author)
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Meulenbelt, I. (author)
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Micali, N. (author)
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Mitchell, K. (author)
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Monteleone, A. M. (author)
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Monteleone, P. (author)
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Munn-Chernoff, M. A. (author)
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Nacmias, B. (author)
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Navratilova, M. (author)
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Ntalla, I. (author)
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O'Toole, J. K. (author)
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Ophoff, R. A. (author)
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Padyukov, L. (author)
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Palotie, A. (author)
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Pantel, J. (author)
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Papezova, H. (author)
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Pinto, D. (author)
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Rabionet, R. (author)
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Raevuori, A. (author)
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Ramoz, N. (author)
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Reichborn-Kjennerud, T. (author)
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Ricca, V. (author)
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Ripatti, S. (author)
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Ritschel, F. (author)
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Roberts, M. (author)
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Rotondo, A. (author)
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Rujescu, D. (author)
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Rybakowski, F. (author)
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Santonastaso, P. (author)
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Scherag, A. (author)
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Scherer, S. W. (author)
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Schmidt, U. (author)
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Schork, N. J. (author)
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Schosser, A. (author)
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Seitz, J. (author)
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Slachtova, L. (author)
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Slagboom, P. E. (author)
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t Landt, Mctso (author)
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Slopien, A. (author)
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Sorbi, S. (author)
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Swiatkowska, B. (author)
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Szatkiewicz, J. P. (author)
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Tachmazidou, I. (author)
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Tenconi, E. (author)
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Tortorella, A. (author)
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Tozzi, F. (author)
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Treasure, J. (author)
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Tsitsika, A. (author)
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Tyszkiewicz-Nwafor, M. (author)
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Tziouvas, K. (author)
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van Elbur, A. A. (author)
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van Furth, E. F. (author)
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Wagner, G. (author)
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Walton, E. (author)
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Widen, E. (author)
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Zeggini, E. (author)
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Zerwas, S. (author)
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Zipfel, S. (author)
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Bergen, A. W. (author)
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Boden, J. M. (author)
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Brandt, H. (author)
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Crawford, S. (author)
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Halmi, K. A. (author)
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Horwood, L. J. (author)
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Johnson, C. (author)
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Kaplan, A. S. (author)
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Kaye, W. H. (author)
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Mitchell, J. E. (author)
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Olsen, C. M. (author)
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Pearson, J. F. (author)
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Pedersen, N. L. (author)
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Strober, M. (author)
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Werge, T. (author)
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Whiteman, D. C. (author)
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Woodside, D. B. (author)
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Stuber, G. D. (author)
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Gordon, S. (author)
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Grove, J. (author)
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Henders, A. K. (author)
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Jureus, A. (author)
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Kirk, K. M. (author)
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Larsen, J. T. (author)
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Parker, R. (author)
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Petersen, L. (author)
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Jordan, J. (author)
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Kennedy, M. (author)
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Montgomery, G. W. (author)
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Wade, T. D. (author)
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- Birgegard, A. (author)
- Karolinska Institutet
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Lichtenstein, P. (author)
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- Norring, C. (author)
- Karolinska Institutet
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Landen, M. (author)
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Martin, N. G. (author)
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Mortensen, P. B. (author)
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- Sullivan, P. F. (author)
- Karolinska Institutet
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Breen, G. (author)
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Bulik, C. M. (author)
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(creator_code:org_t)
- 2019-07-15
- 2019
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 51:8
- Related links:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness(1), affecting 0.9-4% of women and 0.3% of men(2-4), with twin-based heritability estimates of 50-60%(5). Mortality rates are higher than those in other psychiatric disorders(6), and outcomes are unacceptably poor(7). Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)(8,9) and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- ld score regression
- eating-disorders
- genetic correlations
- polygenic
- risk
- comorbidity
- prevalence
- heritability
- variants
- insights
- myc
- Genetics & Heredity
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Watson, H. J.
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Yilmaz, Z.
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Thorntont, L. M.
-
Hubel, C.
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Coleman, J. R. I ...
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Gaspar, H. A.
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show more...
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Bryois, J.
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Adan, Roger A. H ...
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Leppa, V. M.
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Mattheisen, M.
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Medland, S. E.
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Ripke, S.
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Yao, S. Y.
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Giusti-Rodriguez ...
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Hanscombe, K. B.
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Purves, K. L.
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Alfredsson, L.
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Ando, T.
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Andreassen, O. A ...
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Baker, J. H.
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Berrettini, W. H ...
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Boehm, I.
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Boni, C.
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Perica, V. B.
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Buehren, K.
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Burghardt, R.
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Cassina, M.
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Cichon, S.
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Clementi, M.
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Cone, R. D.
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Courtet, P.
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Crow, S.
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Crowley, J. J.
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Danner, U. N.
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Davis, O. S. P.
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de Zwaan, M.
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Dedoussis, G.
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Degortes, D.
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DeSocio, J. E.
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Dick, D. M.
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Dikeos, D.
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Dina, C.
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Dmitrzak-Weglarz ...
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Docampo, E.
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Duncan, L. E.
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Egberts, K.
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Ehrlich, S.
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Escaramis, G.
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Eskos, T.
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Estivill, X.
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Farmer, A.
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Favaro, A.
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Fernandez-Aranda ...
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Fichter, M. M.
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Fischer, K.
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Focker, M.
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Foretova, L.
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Forstner, A. J.
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Forzan, M.
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Franklin, C. S.
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Gallinger, S.
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Giegling, I.
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Giuranna, J.
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Gonidakis, F.
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Gorwood, P.
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Mayora, M. G.
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Guillaume, S.
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Guo, Y. R.
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Hakonarson, H.
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Hatzikotoulas, K ...
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Hauser, J.
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Hebebrand, J.
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Helder, S. G.
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Herms, S.
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Herpertz-Dahlman ...
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Herzog, W.
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Huckins, L. M.
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Hudson, J. I.
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Imgart, H.
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Inoko, H.
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Janout, V.
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Jimenez-Murcia, ...
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Julia, A.
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Kalsi, G.
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Kaminska, D.
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Kaprio, J.
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Karhunen, L.
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Karwautz, A.
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Kas, M. J. H.
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Kennedy, J. L.
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Keski-Rahkonen, ...
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Kiezebrink, K.
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Kim, Y. R.
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Klareskog, L.
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Klump, K. L.
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Knudsen, G. P. S ...
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La Via, M. C.
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Le Hellard, S.
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Levitan, R. D.
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Li, D.
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Lilenfeld, L.
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Lin, B. D.
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Lissowska, J.
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Luykx, J.
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Magistretti, P. ...
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Maj, M.
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Mannik, K.
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Marsal, S.
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Marshall, C. R.
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Mattingsdal, M.
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McDevitt, S.
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McGuffin, P.
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Metspalu, A.
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Meulenbelt, I.
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Micali, N.
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Mitchell, K.
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Monteleone, A. M ...
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Monteleone, P.
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Munn-Chernoff, M ...
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Nacmias, B.
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Navratilova, M.
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Ntalla, I.
-
O'Toole, J. K.
-
Ophoff, R. A.
-
Padyukov, L.
-
Palotie, A.
-
Pantel, J.
-
Papezova, H.
-
Pinto, D.
-
Rabionet, R.
-
Raevuori, A.
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Ramoz, N.
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Reichborn-Kjenne ...
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Ricca, V.
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Ripatti, S.
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Ritschel, F.
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Roberts, M.
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Rotondo, A.
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Rujescu, D.
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Rybakowski, F.
-
Santonastaso, P.
-
Scherag, A.
-
Scherer, S. W.
-
Schmidt, U.
-
Schork, N. J.
-
Schosser, A.
-
Seitz, J.
-
Slachtova, L.
-
Slagboom, P. E.
-
t Landt, Mctso
-
Slopien, A.
-
Sorbi, S.
-
Swiatkowska, B.
-
Szatkiewicz, J. ...
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Tachmazidou, I.
-
Tenconi, E.
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Tortorella, A.
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Tozzi, F.
-
Treasure, J.
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Tsitsika, A.
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Tyszkiewicz-Nwaf ...
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Tziouvas, K.
-
van Elbur, A. A.
-
van Furth, E. F.
-
Wagner, G.
-
Walton, E.
-
Widen, E.
-
Zeggini, E.
-
Zerwas, S.
-
Zipfel, S.
-
Bergen, A. W.
-
Boden, J. M.
-
Brandt, H.
-
Crawford, S.
-
Halmi, K. A.
-
Horwood, L. J.
-
Johnson, C.
-
Kaplan, A. S.
-
Kaye, W. H.
-
Mitchell, J. E.
-
Olsen, C. M.
-
Pearson, J. F.
-
Pedersen, N. L.
-
Strober, M.
-
Werge, T.
-
Whiteman, D. C.
-
Woodside, D. B.
-
Stuber, G. D.
-
Gordon, S.
-
Grove, J.
-
Henders, A. K.
-
Jureus, A.
-
Kirk, K. M.
-
Larsen, J. T.
-
Parker, R.
-
Petersen, L.
-
Jordan, J.
-
Kennedy, M.
-
Montgomery, G. W ...
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Wade, T. D.
-
Birgegard, A.
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Lichtenstein, P.
-
Norring, C.
-
Landen, M.
-
Martin, N. G.
-
Mortensen, P. B.
-
Sullivan, P. F.
-
Breen, G.
-
Bulik, C. M.
-
show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature Genetics
- By the university
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University of Gothenburg
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Karolinska Institutet