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Plasma Cytokine Lev...
Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy.
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- Ernberg, M (author)
- Karolinska Institutet,Karolinska Inst, Sweden; SCON, Sweden
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- Christidis, N (author)
- Karolinska Institutet,Karolinska Inst, Sweden; SCON, Sweden
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- Ghafouri, Bijar (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Bileviciute-Ljungar, I (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Danderyd Hosp, Sweden
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- Löfgren, M (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Danderyd Hosp, Sweden
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- Bjersing, Jan, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg Centre for person-centred care (GPCC),Univ Gothenburg, Sweden
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- Palstam, Annie, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,Sahlgrenska Academy, University of Gothenburg,Univ Gothenburg, Sweden
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- Larsson, Anette, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg Centre for person-centred care (GPCC),Univ Gothenburg, Sweden
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- Mannerkorpi, Kaisa, 1955 (author)
- Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,University of Gothenburg Centre for person-centred care (GPCC),Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,Univ Gothenburg, Sweden
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- Gerdle, Björn (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Kosek, E (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Stockholm Spine Ctr, Sweden
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(creator_code:org_t)
- Hindawi Limited, 2018
- 2018
- English.
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In: Mediators of inflammation. - : Hindawi Limited. - 1466-1861 .- 0962-9351. ; 2018
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Abstract
Subject headings
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- The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and clinical data were analyzed in 125 women with FM and 130 age-matched healthy women. The FM women were then randomized to progressive resistance exercise (n = 49) or relaxation (n = 43). Baseline IL-2, IL-6, TNF-α, IP-10, and eotaxin were higher in FM than in healthy controls (P < 0.041), whereas IL-1β was lower (P < 0.001). There were weak correlations between cytokine levels and clinical variables. After both interventions, IL-1ra had increased (P = 0.004), while IL-1β had increased in the relaxation group (P = 0.002). Changes of IFN-γ, IL-2, IL-4, IL-6, IL-8, and IL-17A were weakly correlated with changes of PPT, but there were no significant correlations between changes of cytokine and changes in other clinical variables. The elevated plasma levels of several cytokines supports the hypothesis that chronic systemic inflammation may underlie the pathophysiology of FM even if the relation to clinical variables was weak. However, 15 weeks of resistance exercise, as performed in this study, did not show any anti-inflammatory effect on neither FM symptoms nor clinical and functional variables. This trial is registered with ClinicalTrials.gov NCT01226784, registered October 21, 2010. The first patient was recruited October 28, 2010.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Keyword
- Adult
- Cytokines
- blood
- Exercise
- physiology
- Female
- Fibromyalgia
- blood
- immunology
- therapy
- Humans
- Inflammation
- blood
- immunology
- therapy
- Interleukin-17
- blood
- Interleukin-1beta
- blood
- Interleukin-2
- blood
- Interleukin-4
- blood
- Interleukin-6
- blood
- Interleukin-8
- blood
- Middle Aged
- Relaxation Therapy
- methods
- Resistance Training
- methods
- Tumor Necrosis Factor-alpha
- blood
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ernberg, M
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Christidis, N
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Ghafouri, Bijar
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Bileviciute-Ljun ...
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Löfgren, M
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Bjersing, Jan, 1 ...
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Palstam, Annie, ...
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Larsson, Anette, ...
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Mannerkorpi, Kai ...
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Gerdle, Björn
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Kosek, E
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
- Articles in the publication
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Mediators of inf ...
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet
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Högskolan Dalarna
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Linköping University