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Mitochondrial prote...
Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma
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- Jang, Su Chul, 1984 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Crescitelli, Rossella, 1985 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Cvjetkovic, Aleksander (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Belgrano, Valerio (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Olofsson Bagge, Roger, 1978 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Sundfeldt, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Ochiya, T. (author)
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Kalluri, R. (author)
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- Lötvall, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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(creator_code:org_t)
- 2019-08-27
- 2019
- English.
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In: Journal of Extracellular Vesicles. - : Wiley. - 2001-3078. ; 8:1
- Related links:
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https://www.tandfonl...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Extracellular vesicles (EVs), including exosomes and microvesicles, are secreted from all cells, and convey messages between cells in health and disease. However, the diversity of EV subpopulations is only beginning to be explored. Since EVs have been implicated in tumour microenvironmental communication, we started to determine the diversity of EVs specifically in this tissue. To do this, we isolated EVs directly from patient melanoma metastatic tissues. Using EV membrane isolation and mass spectrometry analysis, we discovered enrichment of mitochondrial membrane proteins in the melanoma tissue-derived EVs, compared to non-melanoma-derived EVs. Interestingly, two mitochondrial inner membrane proteins MT-CO2 (encoded by the mitochondrial genome) and COX6c (encoded by the nuclear genome) were highly prevalent in the plasma of melanoma patients, as well as in ovarian and breast cancer patients. Furthermore, this subpopulation of EVs contains active mitochondrial enzymes. In summary, tumour tissues are enriched in EVs with mitochondrial membrane proteins and these mitochondrial membrane proteins can be detected in plasma and are increased in melanoma, ovarian cancer as well as breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Extracellular vesicles
- melanoma
- membrane proteins
- mitochondria
- cancer-cells
- exosomes
- membrane
- identification
- biogenesis
- proteomics
- markers
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jang, Su Chul, 1 ...
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Crescitelli, Ros ...
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Cvjetkovic, Alek ...
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Belgrano, Valeri ...
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Olofsson Bagge, ...
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Sundfeldt, Karin ...
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Ochiya, T.
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Kalluri, R.
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Lötvall, Jan, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of Extra ...
- By the university
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University of Gothenburg