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Mature naive B cell...
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Solders, M.Karolinska Institutet
(författare)
Mature naive B cells are retained in the placental intervillous blood and positively associate with specific chemokines in full-term healthy pregnancy
- Artikel/kapitelEngelska2019
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Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/283712
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https://gup.ub.gu.se/publication/283712URI
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https://doi.org/10.1111/aji.13154DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141651299URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Problem Circulating B-cell numbers are lower during pregnancy compared with non-pregnant women, but the underlying reasons for this are unknown. Pregnancy-related hormones could influence B-cell lymphopoiesis in the bone marrow, but B cells may also be recruited to the placenta. To investigate the latter, we examined whether the proportions of total B cells and B cells at different maturational stages in placental intervillous blood (IVB) differ compared with peripheral blood (PB). Method of study From 23 paired samples of PB and IVB following full-term healthy pregnancies, total B cells and immature/transitional, mature/naive, and memory B cells were identified by flow cytometry. Chemokine levels in blood were analyzed using a Luminex assay. Placental explant-derived supernatant was assayed for B-cell chemotactic activity. Results The proportions of total B cells and mature/naive B cells were significantly higher in IVB relative to PB, while the fractions of immature/transitional cells and memory B cells were higher in PB. Multivariate factor analysis demonstrated that a specific chemokine profile in IVB, including CCL20, positively associated with higher proportions of mature/naive B cells in the intervillous space. All B cells expressed CCR6, the corresponding receptor for CCL20, but the intensity of CCR6 expression was significantly higher in mature/naive B cells relative to immature/transitional B cells. Migration assays showed that placental explant-derived supernatants attract B cells. Conclusion These results indicate that B cells, and mature/naive B cells in particular, are retained in the intervillous blood in response to certain chemokines produced by the placenta during late healthy pregnancy.
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Lundell, Anna-Carin,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xaanni
(författare)
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Gorchs, L.Karolinska Institutet
(författare)
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Gidlof, S.Karolinska Institutet
(författare)
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Tiblad, E.Karolinska Institutet
(författare)
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Kaipe, H.Karolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Journal of Reproductive Immunology: Wiley82:31046-74081600-0897
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