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Search: WFRF:(Nyandoro Stephen S. 1975) > (2019) > A New Benzopyranyl ...

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  • Nyandoro, Stephen S.,1975Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Dar Es Salaam, Coll Nat & Appl Sci, Chem Dept, POB 35061, Dar Es Salaam, Tanzania;Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden (author)

A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-07-29
  • MDPI AG,2019

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/283736
  • https://gup.ub.gu.se/publication/283736URI
  • https://doi.org/10.3390/molecules24152746DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-393825URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Phytochemical investigations of ethanol root bark and stem bark extracts of Cleistochlamys kirkii (Benth.) Oliv. (Annonaceae) yielded a new benzopyranyl cadinane-type sesquiterpene (cleistonol, 1) alongside 12 known compounds (2-13). The structures of the isolated compounds were established from NMR spectroscopic and mass spectrometric analyses. Structures of compounds 5 and 10 were further confirmed by single crystal X-ray crystallographic analyses, which also established their absolute stereochemical configuration. The ethanolic crude extract of C. kirkii root bark gave 72% inhibition against the chloroquine-sensitive 3D7-strain malaria parasite Plasmodium falciparum at 0.01 mu g/mL. The isolated metabolites dichamanetin, (E)-acetylmelodorinol, and cleistenolide showed IC50 = 9.3, 7.6 and 15.2 mu M, respectively, against P. falciparum 3D7. Both the crude extract and the isolated compounds exhibited cytotoxicity against the triple-negative, aggressive breast cancer cell line, MDA-MB-231, with IC50 = 42.0 mu g/mL (crude extract) and 9.6-30.7 mu M (isolated compounds). Our findings demonstrate the potential applicability of C. kirkii as a source of antimalarial and anticancer agents.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Maeda, GasperGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Dar Es Salaam, Coll Nat & Appl Sci, Chem Dept, POB 35061, Dar Es Salaam, Tanzania;Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden (author)
  • Munissi, J. J. E.Univ Dar Es Salaam, Coll Nat & Appl Sci, Chem Dept, POB 35061, Dar Es Salaam, Tanzania (author)
  • Gruhonjic, AmraGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden (author)
  • Fitzpatrick, Paul A.Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Univ Gothenburg, Sahlgrenska Canc Ctr, SE-40530 Gothenburg, Sweden(Swepub:gu)xfitpa (author)
  • Lindblad, SofiaUppsala universitet,Organisk kemi(Swepub:uu)sofli642 (author)
  • Duffy, S.Griffith Univ, Griffith Inst Drug Discovery, Discovery Biol, Nathan, Qld 4111, Australia (author)
  • Pelletier, J.McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada (author)
  • Pan, F. F.Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Luoyu Rd 152, Wuhan 430079, Hubei, Peoples R China;Univ Jyvaskyla, Dept Chem, POB 35, FI-40014 Jyvaskyla, Finland (author)
  • Puttreddy, R.Univ Jyvaskyla, Dept Chem, POB 35, FI-40014 Jyvaskyla, Finland (author)
  • Avery, V. M.Griffith Univ, Griffith Inst Drug Discovery, Discovery Biol, Nathan, Qld 4111, Australia (author)
  • Erdelyi, Mate,1975Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Organisk kemi,Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden;(Swepub:uu)mateerde (author)
  • Göteborgs universitetInstitutionen för kemi och molekylärbiologi (creator_code:org_t)

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  • In:Molecules: MDPI AG24:151420-30491431-5157

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