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In vivo detection o...
In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury
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Gorgoraptis, N. (author)
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Li, L. M. (author)
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Whittington, A. (author)
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Zimmerman, K. A. (author)
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Maclean, L. M. (author)
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McLeod, C. (author)
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Ross, E. (author)
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Heslegrave, A. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Passchier, J. (author)
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Matthews, P. M. (author)
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Gunn, R. N. (author)
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McMillan, T. M. (author)
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Sharp, D. J. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2019
- 2019
- English.
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In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 11:508
- Related links:
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http://eprints.gla.a...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Traumatic brain injury (TBI) can trigger progressive neurodegeneration, with tau pathology seen years after a single moderate-severe TBI. Identifying this type of posttraumatic pathology in vivo might help to understand the role of tau pathology in TBI pathophysiology. We used flortaucipir positron emission tomography (PET) to investigate whether tau pathology is present many years after a single TBI in humans. We examined PET data in relation to markers of neurodegeneration in the cerebrospinal fluid (CSF), structural magnetic resonance imaging measures, and cognitive performance. Cerebral flortaucipir binding was variable, with many participants with TBI showing increases in cortical and white matter regions. At the group level, flortaucipir binding was increased in the right occipital cortex in TBI when compared to healthy controls. Flortaucipir binding was associated with increased total tau, phosphorylated tau, and ubiquitin carboxyl-terminal hydrolase L1 CSF concentrations, as well as with reduced fractional anisotropy and white matter tissue density in TBI. Apolipoprotein E (APOE) epsilon 4 genotype affected the relationship between flortaucipir binding and time since injury, CSF beta amyloid 1-42 (A beta 42) concentration, white matter tissue density, and longitudinal Mini-Mental State Examination scores in TBI. The results demonstrate that tau PET is a promising approach to investigating progressive neurodegeneration associated with tauopathy after TBI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- positron-emission-tomography
- amyloid-beta accumulation
- voxel-based
- morphometry
- alzheimers-disease
- cerebrospinal-fluid
- head-injury
- neuropathological criteria
- cognitive impairment
- hydrolase l1
- mouse
- model
- Cell Biology
- Research & Experimental Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gorgoraptis, N.
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Li, L. M.
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Whittington, A.
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Zimmerman, K. A.
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Maclean, L. M.
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McLeod, C.
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show more...
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Ross, E.
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Heslegrave, A.
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Zetterberg, Henr ...
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Passchier, J.
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Matthews, P. M.
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Gunn, R. N.
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McMillan, T. M.
-
Sharp, D. J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Science Translat ...
- By the university
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University of Gothenburg