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Intravenous thrombo...
Intravenous thrombolysis for suspected ischemic stroke with seizure at onset
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Polymeris, A. A. (author)
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Curtze, S. (author)
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Erdur, H. (author)
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Hametner, C. (author)
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Heldner, M. R. (author)
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Groot, A. E. (author)
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Zini, A. (author)
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Bejot, Y. (author)
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Dietrich, A. (author)
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Martinez-Majander, N. (author)
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von Rennenberg, R. (author)
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Gumbinger, C. (author)
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Schaedelin, S. (author)
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De Marchis, G. M. (author)
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Thilemann, S. (author)
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Traenka, C. (author)
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Lyrer, P. A. (author)
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Bonati, L. H. (author)
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Wegener, S. (author)
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Ringleb, P. A. (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Nolte, C. H. (author)
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Scheitz, J. F. (author)
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Arnold, M. (author)
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Strbian, D. (author)
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Nederkoorn, P. J. (author)
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Gensicke, H. (author)
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Engelter, S. T. (author)
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Trisp Collaborators, Trisp Collaborators (author)
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(creator_code:org_t)
- 2019-09-09
- 2019
- English.
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In: Annals of Neurology. - : Wiley. - 0364-5134 .- 1531-8249. ; 86:5, s. 770-779
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https://helda.helsin...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objective Seizure at onset (SaO) has been considered a relative contraindication for intravenous thrombolysis (IVT) in patients with acute ischemic stroke, although this appraisal is not evidence based. Here, we investigated the prognostic significance of SaO in patients treated with IVT for suspected ischemic stroke. Methods In this multicenter, IVT-registry-based study we assessed the association between SaO and symptomatic intracranial hemorrhage (sICH, European Cooperative Acute Stroke Study II definition), 3-month mortality, and 3-month functional outcome on the modified Rankin Scale (mRS) using unadjusted and adjusted logistic regression, coarsened exact matching, and inverse probability weighted analyses. Results Among 10,074 IVT-treated patients, 146 (1.5%) had SaO. SaO patients had significantly higher National Institutes of Health Stroke Scale score and glucose on admission, and more often female sex, prior stroke, and prior functional dependence than non-SaO patients. In unadjusted analysis, they had generally less favorable outcomes. After controlling for confounders in adjusted, matched, and weighted analyses, all associations between SaO and any of the outcomes disappeared, including sICH (odds ratio [OR](unadjusted) = 1.53 [95% confidence interval (CI) = 0.74-3.14], ORadjusted = 0.52 [95% CI = 0.13-2.16], ORmatched = 0.68 [95% CI = 0.15-3.03], ORweighted = 0.95 [95% CI = 0.39-2.32]), mortality (ORunadjusted = 1.49 [95% CI = 1.00-2.24], ORadjusted = 0.98 [95% CI = 0.5-1.92], ORmatched = 1.13 [95% CI = 0.55-2.33], ORweighted = 1.17 [95% CI = 0.73-1.88]), and functional outcome (mRS >= 3/ordinal mRS: ORunadjusted = 1.33 [95% CI = 0.96-1.84]/1.35 [95% CI = 1.01-1.81], ORadjusted = 0.78 [95% CI = 0.45-1.32]/0.78 [95% CI = 0.52-1.16], ORmatched = 0.75 [95% CI = 0.43-1.32]/0.45 [95% CI = 0.10-2.06], ORweighted = 0.87 [95% CI = 0.57-1.34]/1.00 [95% CI = 0.66-1.52]). These results were consistent regardless of whether patients had an eventual diagnosis of ischemic stroke (89/146) or stroke mimic (57/146 SaO patients). Interpretation SaO was not an independent predictor of poor prognosis. Withholding IVT from patients with assumed ischemic stroke presenting with SaO seems unjustified. ANN NEUROL 2019
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Keyword
- health-care professionals
- early management
- plasminogen-activator
- mimics
- guidelines
- alteplase
- safety
- classification
- association
- population
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Polymeris, A. A.
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Curtze, S.
-
Erdur, H.
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Hametner, C.
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Heldner, M. R.
-
Groot, A. E.
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show more...
-
Zini, A.
-
Bejot, Y.
-
Dietrich, A.
-
Martinez-Majande ...
-
von Rennenberg, ...
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Gumbinger, C.
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Schaedelin, S.
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De Marchis, G. M ...
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Thilemann, S.
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Traenka, C.
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Lyrer, P. A.
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Bonati, L. H.
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Wegener, S.
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Ringleb, P. A.
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Tatlisumak, Turg ...
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Nolte, C. H.
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Scheitz, J. F.
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Arnold, M.
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Strbian, D.
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Nederkoorn, P. J ...
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Gensicke, H.
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Engelter, S. T.
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Trisp Collaborat ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nursing
- Articles in the publication
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Annals of Neurol ...
- By the university
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University of Gothenburg