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Associations betwee...
Associations between autistic-like traits and polymorphisms in NFKBIL1
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- Strenn, Nina, 1984 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Hovey, Daniel (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Jonsson, Lina, 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Anckarsäter, Henrik, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Centrum för etik, juridik och mental hälsa,Centre for Ethics, Law, and Mental Health
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- Lundström, Sebastian (författare)
- Gothenburg University,Göteborgs universitet,Centrum för etik, juridik och mental hälsa,Gillbergcentrum,Centre for Ethics, Law, and Mental Health,Gillberg Neuropsychiatry Centre
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- Lichtenstein, P. (författare)
- Karolinska Institutet
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- Ekman, Agneta, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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(creator_code:org_t)
- 2019-06-04
- 2019
- Engelska.
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Ingår i: Acta Neuropsychiatrica. - : Cambridge University Press (CUP). - 0924-2708 .- 1601-5215. ; 31:4, s. 220-229
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective:The immune system has been suggested to be associated with neuropsychiatric disorders; for example, elevated levels of cytokines and the inflammation-related transcription factor nuclear factor kappa-B (NF-κB) have been reported in individuals with autism spectrum disorder (ASD). The aim of this study was to investigate possible associations between autistic-like traits (ALTs) and single nucleotide polymorphisms (SNPs) in NFKB1 (encoding a subunit of the NF-κB protein complex) and NF-κB inhibitor-like protein 1 (NFKBIL1).Methods:The study was conducted in a cohort from the general population: The Child and Adolescent Twin Study in Sweden (CATSS, n = 12 319, 9-12 years old). The subjects were assessed by the Autism-Tics, ADHD, and Other Comorbidities Inventory. Five SNPs within the two genes were genotyped (NFKBIL1: rs2857605, rs2239707, rs2230365 and rs2071592; NFKB1: rs4648022).Results:We found significant associations for two SNPs in NFKBIL1: rs2239707 showed a significant distribution of genotype frequencies in the case-control analysis both for all individuals combined and in boys only, and rs2230365 was significantly associated with the ALTs-module language impairment in boys only. Furthermore, we found nominal association in the case-control study for rs2230365, replicating earlier association between this SNP and ASD in an independent genome-wide association study.Conclusion:The shown associations between polymorphisms in NFKBIL1 and ALTs are supporting an influence of the immune system on neuropsychiatric symptoms. © Scandinavian College of Neuropsychopharmacology 2019.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- autistic disorders
- immune system
- polymorphism
- single nucleotide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Strenn, Nina, 19 ...
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Hovey, Daniel
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Jonsson, Lina, 1 ...
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Anckarsäter, Hen ...
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Lundström, Sebas ...
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Lichtenstein, P.
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Ekman, Agneta, 1 ...
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Göteborgs universitet
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Karolinska Institutet