id:"swepub:oai:gup.ub.gu.se/285279"
Search: id:"swepub:oai:gup.ub.gu.se/285279" > Plasticity in exocy...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Gu, Chaoyi,1992Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)
Plasticity in exocytosis revealed through the effects of repetitive stimuli affect the content of nanometer vesicles and the fraction of transmitter released
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019-09-30
- Proceedings of the National Academy of Sciences,2019
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/285279
- https://gup.ub.gu.se/publication/285279URI
- https://doi.org/10.1073/pnas.1910859116DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Electrochemical techniques with disk and nano-tip electrodes, together with calcium imaging, were used to examine the effect of short-interval repetitive stimuli on both exocytosis and vesicular content in a model cell line. We show that the number of events decreases markedly with repeated stimuli suggesting a depletion of exocytosis machinery. However, repetitive stimuli induce a more stable fusion pore, leading to an increased amount of neurotransmitter release. In contrast, the total neurotransmitter content inside the vesicles decreases after repetitive stimuli, resulting in a higher average release fraction from each event. We suggest a possible mechanism regarding a link between activity-induced plasticity and fraction of release.
Subject headings and genre
- NATURVETENSKAP Kemi Oorganisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Inorganic Chemistry hsv//eng
- amperometry
- vesicle impact electrochemical cytometry
- exocytosis
- repetitive stimuli
- plasticity
- protein-kinase-c
- activity-dependent potentiation
- catecholamine
- release
- quantal size
- fusion pore
- chromaffin
- cells
- pheochromocytoma
- activation
- dynamin
- Science & Technology - Other Topics
Added entries (persons, corporate bodies, meetings, titles ...)
- Larsson, AnnaGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xlaral (author)
- Ewing, Andrew G,1957Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xewian (author)
- Göteborgs universitetInstitutionen för kemi och molekylärbiologi (creator_code:org_t)
Related titles
- In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences116:43, s. 21409-214150027-8424
- In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences116:43, s. 21409-214151091-6490
Internet link
Find in a library
- Proceedings of the National Academy of Sciences of the United States of America (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Gu, Chaoyi, 1992
- Larsson, Anna
- Ewing, Andrew G, ...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Chemical Science ...
- and Inorganic Chemis ...
- Articles in the publication
- Proceedings of t ...
- Proceedings of t ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
