WFRF:(Bouza E.)
Sökning: WFRF:(Bouza E.) > Candida infective e...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04684naa a2200853 4500 | |
| 001 | oai:gup.ub.gu.se/285405 | |
| 003 | SwePub | |
| 008 | 240528s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2854052 URI |
| 024 | 7 | a https://doi.org/10.1007/s10096-008-0466-x2 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Baddley, J W4 aut |
| 245 | 1 0 | a Candida infective endocarditis. |
| 264 | c 2008-02-19 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2008 |
| 520 | a Candida infective endocarditis (IE) is uncommon but often fatal. Most epidemiologic data are derived from small case series or case reports. This study was conducted to explore the epidemiology, treatment patterns, and outcomes of patients with Candida IE. We compared 33 Candida IE cases to 2,716 patients with non-fungal IE in the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS). Patients were enrolled and the data collected from June 2000 until August 2005. We noted that patients with Candida IE were more likely to have prosthetic valves (p < 0.001), short-term indwelling catheters (p < 0.0001), and have healthcare-associated infections (p < 0.001). The reasons for surgery differed between the two groups: myocardial abscess (46.7% vs. 22.2%, p = 0.026) and persistent positive blood cultures (33.3% vs. 9.9%, p = 0.003) were more common among those with Candida IE. Mortality at discharge was higher in patients with Candida IE (30.3%) when compared to non-fungal cases (17%, p = 0.046). Among Candida patients, mortality was similar in patients who received combination surgical and antifungal therapy versus antifungal therapy alone (33.3% vs. 27.8%, p = 0.26). New antifungal drugs, particularly echinocandins, were used frequently. These multi-center data suggest distinct epidemiologic features of Candida IE when compared to non-fungal cases. Indications for surgical intervention are different and mortality is increased. Newer antifungal treatment options are increasingly used. Large, multi-center studies are needed to help better define Candida IE. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Antifungal Agents | |
| 653 | a therapeutic use | |
| 653 | a Candida | |
| 653 | a isolation & purification | |
| 653 | a Candidiasis | |
| 653 | a drug therapy | |
| 653 | a epidemiology | |
| 653 | a microbiology | |
| 653 | a mortality | |
| 653 | a Catheters | |
| 653 | a Indwelling | |
| 653 | a Cross Infection | |
| 653 | a Endocarditis | |
| 653 | a drug therapy | |
| 653 | a epidemiology | |
| 653 | a microbiology | |
| 653 | a mortality | |
| 653 | a Female | |
| 653 | a Humans | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Prostheses and Implants | |
| 653 | a Risk Factors | |
| 700 | 1 | a Benjamin, D K4 aut |
| 700 | 1 | a Patel, M4 aut |
| 700 | 1 | a Miró, J4 aut |
| 700 | 1 | a Athan, E4 aut |
| 700 | 1 | a Barsic, B4 aut |
| 700 | 1 | a Bouza, E4 aut |
| 700 | 1 | a Clara, L4 aut |
| 700 | 1 | a Elliott, T4 aut |
| 700 | 1 | a Kanafani, Z4 aut |
| 700 | 1 | a Klein, J4 aut |
| 700 | 1 | a Lerakis, S4 aut |
| 700 | 1 | a Levine, D4 aut |
| 700 | 1 | a Spelman, D4 aut |
| 700 | 1 | a Rubinstein, E4 aut |
| 700 | 1 | a Tornos, P4 aut |
| 700 | 1 | a Morris, A J4 aut |
| 700 | 1 | a Pappas, P4 aut |
| 700 | 1 | a Fowler, V G4 aut |
| 700 | 1 | a Chu, V H4 aut |
| 700 | 1 | a Cabell, C4 aut |
| 700 | 1 | a Olaison, Lars,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xolala |
| 710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för infektionssjukdomar4 org |
| 773 | 0 | t European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiologyd : Springer Science and Business Media LLCg 27:7, s. 519-29q 27:7<519-29x 0934-9723 |
| 773 | 0 | t European Journal of Clinical Microbiology & Infectious Diseasesd : Springer Science and Business Media LLCg 27:7, s. 519-29q 27:7<519-29x 1435-4373 |
| 856 | 4 | u https://europepmc.org/articles/pmc2757733?pdf=render |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/285405 |
| 856 | 4 8 | u https://doi.org/10.1007/s10096-008-0466-x |
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