Sökning: WFRF:(Wikkelsö Carsten 1947) >
Survival in treated...
Survival in treated idiopathic normal pressure hydrocephalus
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- Andrén, Kerstin, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,University of Gothenburg, Sweden,Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Hydrocephalus Res Unit,Dept Clin Neurosci, Bla Straket 7, S-41345 Gothenburg, Sweden
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- Wikkelsö, Carsten, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,University of Gothenburg, Sweden,Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Hydrocephalus Res Unit,Dept Clin Neurosci, Bla Straket 7, S-41345 Gothenburg, Sweden
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- Sundström, Nina (författare)
- Umeå universitet,Radiofysik,Umeå universitet, Radiofysik, Sweden,Umea Univ, Dept Radiat Sci, Biomed Engn, Umea, Sweden
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- Israelsson, Hanna, 1983- (författare)
- Umeå universitet,Klinisk neurovetenskap,Umeå universitet, Klinisk neurovetenskap, Sweden,Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden
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- Agerskov, Simon (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,University of Gothenburg, Sweden,Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Hydrocephalus Res Unit,Dept Clin Neurosci, Bla Straket 7, S-41345 Gothenburg, Sweden
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- Laurell, Katarina, 1967- (författare)
- Uppsala universitet,Umeå universitet,Klinisk neurovetenskap,Department of Neuroscience, Uppsala University, Uppsala, Sweden,Umeå universitet, Klinisk neurovetenskap, Sweden,Landtblom: Neurovetenskap,Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden
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- Hellström, Per (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,University of Gothenburg, Sweden,Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Hydrocephalus Res Unit,Dept Clin Neurosci, Bla Straket 7, S-41345 Gothenburg, Sweden
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- Tullberg, Mats, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,University of Gothenburg, Sweden,Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Hydrocephalus Res Unit,Dept Clin Neurosci, Bla Straket 7, S-41345 Gothenburg, Sweden
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(creator_code:org_t)
- 2019-11-11
- 2020
- Engelska.
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Ingår i: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 267, s. 640-648
- Relaterad länk:
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https://link.springe...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective To describe survival and causes of death in 979 treated iNPH patients from the Swedish Hydrocephalus Quality Registry (SHQR), and to examine the influence of comorbidities, symptom severity and postoperative outcome. Methods All 979 patients operated for iNPH 2004-2011 and registered in the SHQR were included. A matched control group of 4890 persons from the general population was selected by Statistics Sweden. Data from the Swedish Cause of Death Registry was obtained for patients and controls. Results At a median 5.9 (IQR 4.2-8.1) year follow-up, 37% of the iNPH patients and 23% of the controls had died. Mortality was increased in iNPH patients by a hazard ratio of 1.81, 95% CI 1.61-2.04, p < 0.001. More pronounced symptoms in the preoperative ordinal gait scale and the Mini-mental State Examination were the most important independent predictors of mortality along with the prevalence of heart disease. Patients who improved in both the gait scale and in the modified Rankin Scale postoperatively (n = 144) had a similar survival as the general population (p = 0.391). Deaths due to cerebrovascular disease or dementia were more common in iNPH patients, while more controls died because of neoplasms or disorders of the circulatory system. Conclusions Mortality in operated iNPH patients is 1.8 times increased compared to the general population, a lower figure than previously reported. The survival of iNPH patients who improve in gait and functional independence is similar to that of the general population, indicating that shunt surgery for iNPH, besides improving symptoms and signs, can normalize survival.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Hydrocephalus
- Gait disorders
- Cognitive disorders
- Prognosis
- Cohort
- studies
- shunt surgery
- prevalence
- risk
- Neurosciences & Neurology
- Hydrocephalus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Andrén, Kerstin, ...
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Wikkelsö, Carste ...
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Sundström, Nina
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Israelsson, Hann ...
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Agerskov, Simon
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Laurell, Katarin ...
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visa fler...
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Hellström, Per
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Tullberg, Mats, ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Journal of Neuro ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Linköpings universitet
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Uppsala universitet