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  • Carrera, Caty (author)

Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA.

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/286990
  • https://gup.ub.gu.se/publication/286990URI
  • https://doi.org/10.1212/WNL.0000000000007997DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • To validate the Genot-PA score, a clinical-genetic logistic regression score that stratifies the thrombolytic therapy safety, in a new cohort of patients with stroke.We enrolled 1,482 recombinant tissue plasminogen activator (rtPA)-treated patients with stroke in Spain and Finland from 2003 to 2016. Cohorts were analyzed on the basis of ethnicity and therapy: Spanish patients treated with IV rtPA within 4.5 hours of onset (cohort A and B) or rtPA in combination with mechanical thrombectomy within 6 hours of onset (cohort C) and Finnish participants treated with IV rtPA within 4.5 hours of onset (cohort D). The Genot-PA score was calculated, and hemorrhagic transformation (HT) and parenchymal hematoma (PH) risks were determined for each score stratum.Genot-PA score was tested in 1,324 (cohort A, n = 726; B, n = 334; C, n = 54; and D, n = 210) patients who had enough information to complete the score. Of these, 213 (16.1%) participants developed HT and 85 (6.4%) developed PH. In cohorts A, B, and D, HT occurrence was predicted by the score (p = 2.02 × 10-6, p = 0.023, p = 0.033); PH prediction was associated in cohorts A through C (p = 0.012, p = 0.034, p = 5.32 × 10-4). Increased frequency of PH events from the lowest to the highest risk group was found (cohort A 4%-15.7%, cohort B 1.5%-18.2%, cohort C 0%-100%). The best odds ratio for PH prediction in the highest-risk group was obtained in cohort A (odds ratio 5.16, 95% confidence interval 1.46-18.08, p = 0.009).The Genot-PA score predicts HT in patients with stroke treated with IV rtPA. Moreover, in an exploratory study, the score was associated with PH risk in mechanical thrombectomy-treated patients.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Cullell, Natalia (author)
  • Torres-Águila, Nuria (author)
  • Muiño, Elena (author)
  • Bustamante, Alejandro (author)
  • Dávalos, Antonio (author)
  • López-Cancio, Elena (author)
  • Ribó, Marc (author)
  • Molina, Carlos A (author)
  • Giralt-Steinhauer, Eva (author)
  • Soriano-Tárraga, Carolina (author)
  • Mola-Caminal, Marina (author)
  • Jiménez-Conde, Jordi (author)
  • Roquer, Jaume (author)
  • Vives-Bauza, Cristófol (author)
  • Navarro, Rosa Díaz (author)
  • Obach, Victor (author)
  • Arenillas, Juan Francisco (author)
  • Segura, Tomás (author)
  • Serrano-Heras, Gemma (author)
  • Martí-Fàbregas, Joan (author)
  • Freijo, Marimar (author)
  • Cabezas, Juan Antonio (author)
  • Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt (author)
  • Heitsch, Laura (author)
  • Ibañez, Laura (author)
  • Cruchaga, Carlos (author)
  • Lee, Jin-Moo (author)
  • Strbian, Daniel (author)
  • Montaner, Joan (author)
  • Fernández-Cadenas, Israel (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap (creator_code:org_t)

Related titles

  • In:Neurology93:91526-632X

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