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Cerebrospinal fluid...
Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition.
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Osborn, Katie E (author)
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Khan, Omair A (author)
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Kresge, Hailey A (author)
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Bown, Corey W (author)
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Liu, Dandan (author)
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Moore, Elizabeth E (author)
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Gifford, Katherine A (author)
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Acosta, Lealani Mae Y (author)
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Bell, Susan P (author)
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Hohman, Timothy J (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Jefferson, Angela L (author)
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(creator_code:org_t)
- 2019-12
- 2019
- English.
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In: Alzheimer's & dementia. - : Wiley. - 2352-8729. ; 11:C, s. 700-709
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Neuroaxonal damage may contribute to cognitive changes preceding clinical dementia. Accessible biomarkers are critical for detecting such damage.Plasma and cerebrospinal fluid (CSF) neurofilament light (NFL) were related to neuropsychological performance among Vanderbilt Memory & Aging Project participants (plasma n=333, 73±7years; CSF n=149, 72±6years) ranging from normal cognition (NC) to mild cognitive impairment (MCI). Models adjusted for age, sex, race/ethnicity, education, apolipoprotein E ε4 carriership,and Framingham Stroke Risk Profile.Plasma NFL was related to all domains (P values ≤ .008) except processing speed (P values ≥ .09). CSF NFL was related to memory and language (P values ≤ .04). Interactions with cognitive diagnosis revealed widespread plasma associations, particularly in MCI participants, which were further supported in head-to-head comparison models.Plasma and CSF NFL (reflecting neuroaxonal injury) relate to cognition among non-demented older adults albeit with small to medium effects. Plasma NFL shows particular promise as an accessible biomarker with relevance to cognition in MCI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Osborn, Katie E
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Khan, Omair A
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Kresge, Hailey A
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Bown, Corey W
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Liu, Dandan
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Moore, Elizabeth ...
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show more...
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Gifford, Katheri ...
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Acosta, Lealani ...
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Bell, Susan P
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Hohman, Timothy ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Jefferson, Angel ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & de ...
- By the university
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University of Gothenburg