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  • Sundberg, JonasGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg, Sweden. (författare)

Recurrence rates after surgical removal of oral leukoplakia-A prospective longitudinal multi-centre study.

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-12-06
  • Public Library of Science (PLoS),2019

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/287805
  • https://gup.ub.gu.se/publication/287805URI
  • https://doi.org/10.1371/journal.pone.0225682DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413864URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Oral leukoplakia (OL) is a potentially malignant oral disorder. The Gold Standard treatment is to remove surgically the OL. Despite optimal surgery, the recurrence rates are estimated to be 30%. The reason for this is unknown. The aim of this study was to investigate the clinical factors that correlate with recurrence after surgical removal of OL. In a prospective study data were collected from 226 patients with OL. Forty-six patients were excluded due to incomplete records or concomitant presence of other oral mucosal diseases. Overall, 180 patients proceeded to analysis (94 women and 86 men; mean age, 62 years; age range, 28-92 years). Clinical data, such as gender, diagnosis (homogeneous/non-homogeneous leukoplakia), location, size, tobacco and alcohol use, verified histopathological diagnosis, and clinical photograph, were obtained. In patients who were eligible for surgery, the OL was surgically removed with a margin. To establish recurrence, a healthy mucosa between the surgery and recurrence had to be confirmed in the records or clinical photographs. Statistical analysis was performed with the level of significance set at P<0.05. Of the 180 patients diagnosed with OL, 57% (N = 103) underwent surgical removal in toto. Recurrence was observed in 43 OL. The cumulative incidence of recurrence of OL was 45% after 4 years and 49% after 5 years. Fifty-six percent (N = 23) of the non-homogeneous type recurred. Among snuff-users 73% (N = 8) cases of OL recurred. A non-homogeneous type of OL and the use of snuff were significantly associated with recurrence after surgical excision (P = 0.021 and P = 0.003, respectively). Recurrence was also significantly associated with cancer transformation (P<0.001). No significant differences were found between recurrence and any of the following: dysplasia, site of lesion, size, multiple vs. solitary OL, gender, age, use of alcohol or smoking. In conclusion, clinical factors that predict recurrence of OL are non-homogeneous type and use of snuff.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Korytowska, MagdalenaNAL Hosp, Clin Orofacial Med, Trollhattan, Region Vastra G, Sweden. (författare)
  • Holmberg, Erik,1951Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.(Swepub:gu)xholer (författare)
  • Bratel, JohnClin Oral Med, Gothenburg, Region Vastra G, Sweden. (författare)
  • Wallström, MatsClin Oral & Maxillofacial Surg, Gothenburg, Region Vastra G, Sweden. (författare)
  • Kjellström, EbbaUppsala universitet,Käkkirurgi (författare)
  • Blomgren, JohanSahlgrenska Univ Hosp East, Clin Oral Med, Gothenburg, Region Vastra G, Sweden. (författare)
  • Kovács, AnikóSahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg, Sweden. (författare)
  • Öhman, JennyGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg, Sweden.(Swepub:gu)xohmje (författare)
  • Sand, LarsUniv Oslo, Fac Odontol, Dept Oral Biol, Oslo, Norway. (författare)
  • Hirsch, Jan-MichaelUppsala universitet,Käkkirurgi(Swepub:uu)jahir257 (författare)
  • Giglio, Daniel,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.(Swepub:gu)xgigda (författare)
  • Kjeller, GöranGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Clin Oral & Maxillofacial Surg, Gothenburg, Region Vastra G, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral & Maxillofacial Surg, Gothenburg, Sweden.(Swepub:gu)xzelgr (författare)
  • Hasséus, Bengt,1955Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg, Sweden.;Clin Oral Med, Gothenburg, Region Vastra G, Sweden.(Swepub:gu)xhasbe (författare)
  • Göteborgs universitetInstitutionen för odontologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PloS one: Public Library of Science (PLoS)14:121932-6203

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  • PloS one (Sök värdpublikationen i LIBRIS)

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