The human secretome

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Uhlén, MathiasKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden;Tech Univ Denmark, Ctr Biosustainabil, Lyngby, Denmark;Karolinska Inst, Dept Neurosci, Stockholm, Sweden (author)

The human secretome

Article/chapterEnglish2019

Publisher, publication year, extent ...

American Association for the Advancement of Science (AAAS),2019

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/287931
https://gup.ub.gu.se/publication/287931URI
https://doi.org/10.1126/scisignal.aaz0274DOI
https://research.chalmers.se/publication/514448URI
https://research.chalmers.se/publication/514253URI
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-265462URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400051URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:142395621URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

QC 20191218
The proteins secreted by human cells (collectively referred to as the secretome) are important not only for the basic understanding of human biology but also for the identification of potential targets for future diagnostics and therapies. Here, we present a comprehensive analysis of proteins predicted to be secreted in human cells, which provides information about their final localization in the human body, including the proteins actively secreted to peripheral blood. The analysis suggests that a large number of the proteins of the secretome are not secreted out of the cell, but instead are retained intracellularly, whereas another large group of proteins were identified that are predicted to be retained locally at the tissue of expression and not secreted into the blood. Proteins detected in the human blood by mass spectrometry-based proteomics and antibody-based immuno-assays are also presented with estimates of their concentrations in the blood. The results are presented in an updated version 19 of the Human Protein Atlas in which each gene encoding a secretome protein is annotated to provide an open-access knowledge resource of the human secretome, including body-wide expression data, spatial localization data down to the single-cell and subcellular levels, and data about the presence of proteins that are detectable in the blood.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
NATURVETENSKAP Biologi Bioinformatik och systembiologi hsv//swe
NATURAL SCIENCES Biological Sciences Bioinformatics and Systems Biology hsv//eng
NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
NATURVETENSKAP Biologi Cellbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
protein import
Biochemistry & Molecular Biology
Cell Biology

Added entries (persons, corporate bodies, meetings, titles ...)

Karlsson, Max J.KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1hm1ssx (author)
Hober, AndreasKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u15bkxsl (author)
Svensson, Anne-SophieKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1t0mckt (author)
Scheffel, JuliaKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1y97f4h (author)
Kotol, DavidKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1yd1hdh (author)
Zhong, WenKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1xwoji3 (author)
Tebani, AbdellahKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u17jnmwg (author)
Strandberg, LinneaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1jy95lk (author)
Edfors, FredrikKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden;Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA(Swepub:kth)u149ml0e (author)
Sjostedt, E.Karolinska Institutet,Karolinska Inst, Dept Neurosci, Stockholm, Sweden. (author)
Schwenk, Jochen M.Karolinska Institutet,KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1h7wtme (author)
Mardinoglu, AdilKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1t8kmr6 (author)
Berling, AnnaKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u18q4b67 (author)
Ekblad, SiriKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u13gulih (author)
Dannemeyer, MelanieKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1u0d39z (author)
Kanje, Sara,1986-KTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1t204cn (author)
Rockberg, JohanKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u130jo0a (author)
Lundqvist, MagnusKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1hfekeg (author)
Malm, MagdalenaKTH,Proteinvetenskap(Swepub:kth)u1cmkpee (author)
Volk, Anna-LuisaKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1j049o2 (author)
Nilsson, PeterKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1ws88sk (author)
Månberg, Anna,1985-KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1g5roxd (author)
Dodig-Crnkovic, TeaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1wrth1x (author)
Pin, E.KTH,Sci Life Lab, Dept Prot Sci, Stockholm, Sweden.,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden (author)
Zwahlen, M.KTH,Sci Life Lab, Dept Prot Sci, Stockholm, Sweden.,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden (author)
Oksvold, P.KTH,Sci Life Lab, Dept Prot Sci, Stockholm, Sweden.,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden (author)
von Feilitzen, KalleKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1dbmi38 (author)
Häussler, Ragna S.KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1izv3pd (author)
Hong, Mun-GwanKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u19gmsru (author)
Lindskog, CeciliaUppsala universitet,Klinisk och experimentell patologi(Swepub:uu)cecli129 (author)
Pontén, FredrikUppsala universitet,Klinisk och experimentell patologi(Swepub:uu)fredpont (author)
Katona, BorbalaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)borka244 (author)
Vuu, JimmyUppsala universitet,Klinisk och experimentell patologi(Swepub:uu)jimvu995 (author)
Lindström, EmilUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)emili335 (author)
Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Chem & Biol Engn, Gothenburg, Sweden.(Swepub:cth)nielsenj (author)
Robinson, Jonathan,1986Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Chem & Biol Engn, Gothenburg, Sweden.(Swepub:cth)jonrob (author)
Ayoglu, BurcuKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1kfjubd (author)
Mahdessian, DianaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1gwp2ka (author)
Sullivan, DevinKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u17a9k6f (author)
Thul, PeterKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1j34ncc (author)
Danielsson, FridaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1cx4q8o (author)
Stadler, CharlotteKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1r100ik (author)
Lundberg, EmmaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u12bylj1 (author)
Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Physiol, Gothenburg, Region Vastra G, Sweden.(Swepub:gu)xbgort (author)
Gummesson, Anders,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.(Swepub:gu)xguman (author)
Voldborg, B. G.Danmarks Tekniske Universitet,Technical University of Denmark,Tech Univ Denmark, Ctr Biosustainabil, Lyngby, Denmark. (author)
Tegel, HannaKTH,Proteinvetenskap,Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden.,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1nou8yx (author)
Hober, SophiaKTH,Proteinvetenskap,KTH Royal Inst Technol, Albanova Univ Ctr, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u11qqzc1 (author)
Forsström, BjörnKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u11i5nju (author)
Schwenk, J. M.Karolinska Inst, Dept Neurosci, Stockholm, Sweden (author)
Fagerberg, LinnKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u1dglfid (author)
Sivertsson, ÅsaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden(Swepub:kth)u195d5b0 (author)
KTHProteinvetenskap (creator_code:org_t)

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By the author/editor: Uhlén, Mathias; Karlsson, Max J.; Hober, Andreas; Svensson, Anne-S ...; Scheffel, Julia; Kotol, David; show more...; Zhong, Wen; Tebani, Abdellah; Strandberg, Linn ...; Edfors, Fredrik; Sjostedt, E.; Schwenk, Jochen ...; Mardinoglu, Adil; Berling, Anna; Ekblad, Siri; Dannemeyer, Mela ...; Kanje, Sara, 198 ...; Rockberg, Johan; Lundqvist, Magnu ...; Malm, Magdalena; Volk, Anna-Luisa; Nilsson, Peter; Månberg, Anna, 1 ...; Dodig-Crnkovic, ...; Pin, E.; Zwahlen, M.; Oksvold, P.; von Feilitzen, K ...; Häussler, Ragna ...; Hong, Mun-Gwan; Lindskog, Cecili ...; Pontén, Fredrik; Katona, Borbala; Vuu, Jimmy; Lindström, Emil; Nielsen, Jens B, ...; Robinson, Jonath ...; Ayoglu, Burcu; Mahdessian, Dian ...; Sullivan, Devin; Thul, Peter; Danielsson, Frid ...; Stadler, Charlot ...; Lundberg, Emma; Bergström, Göran ...; Gummesson, Ander ...; Voldborg, B. G.; Tegel, Hanna; Hober, Sophia; Forsström, Björn; Schwenk, J. M.; Fagerberg, Linn; Sivertsson, Åsa; show less...

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