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  • Abrahamsson, Jonas,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics (author)

Use of granulocyte colony-stimulating factor and risk of relapse in pediatric patients treated for acute myeloid leukemia according to NOPHO-AML 2004 and DB AML-01.

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-03-07
  • Wiley,2019

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/288889
  • https://gup.ub.gu.se/publication/288889URI
  • https://doi.org/10.1002/pbc.27701DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-383500URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Supportive-care use of granulocyte colony-stimulating factor (G-CSF) in pediatric acute myeloid leukemia (AML) remains controversial due to a theoretical increased risk of relapse and limited impact on neutropenic complications. We describe the use of G-CSF in patients treated according to NOPHO-AML 2004 and DB AML-01 and investigated associations with relapse.Patients diagnosed with de novo AML completing the first week of therapy and not treated with hematopoietic stem cell transplantation in the first complete remission were included (n=367). Information on G-CSF treatment after each course (yes/no) was registered prospectively in the study database and detailed information was gathered retrospectively from each center. Descriptive statistics were used to describe G-CSF use and Cox regression to assess the association between G-CSF and risk of relapse.G-CSF as supportive care was given to 128 (35%) patients after 268 (39%) courses, with a large variation between centers (0-93%). The use decreased with time-the country-adjusted odds ratio was 0.8/diagnostic year (95% confidence interval [CI] 0.7-0.9). The median daily dose was 5 μg/kg (range 3-12 μg/kg) and the median cumulative dose was 75 μg/kg (range 7-1460 μg/kg). Filgrastim was used in 82% of G-CSF administrations and infection was the indication in 44% of G-CSF administrations. G-CSF was associated with increased risk of relapse-the adjusted hazard ratio was 1.5 (95% CI 1.1-2.2).G-CSF as supportive care was used in a third of patients, and use decreased with time. Our results indicate that the use of G-CSF may be associated with an increased risk of relapse.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Asdahl, Peter HAarhus Univ Hosp, Dept Hematol, Aarhus, Denmark,Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark (author)
  • Abrahamsson, Jonas,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark(Swepub:gu)xabrjo (author)
  • Ha, Shau-YinQueen Mary Hosp, Dept Pediat, Hong Kong, Peoples R China;HKPHOSG, Hong Kong, Peoples R China (author)
  • Jónsson, Ólafur GLandspitali Univ Hosp, Dept Pediat, Reykjavik, Iceland (author)
  • Kaspers, Gertjan J LVrije Univ Amsterdam Med Ctr, Dept Pediat, Amsterdam, Netherlands;Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands;Dutch Childhood Oncol Grp, The Hague, Netherlands (author)
  • Koskenvuo, MinnaUniv Helsinki, Div Hematol Oncol & Stem Cell Transplantat, New Childrens Hosp, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland (author)
  • Lausen, BirgitteUniv Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark (author)
  • De Moerloose, BarbaraGhent Univ Hosp, Dept Pediat Hematol Oncol & Stem Cell Transplanta, Ghent, Belgium (author)
  • Palle, Josefine,1964-Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)jopal516 (author)
  • Zeller, BernwardOslo Univ Hosp, Div Pediat & Adolescent Med, Oslo, Norway (author)
  • Hasle, Henrik (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik (creator_code:org_t)

Related titles

  • In:Pediatric blood & cancer: Wiley66:61545-50171545-5009

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