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Comparing different...
Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes.
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Lee, Crystal Man Ying (författare)
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Colagiuri, Stephen (författare)
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Woodward, Mark (författare)
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visa fler...
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Gregg, Edward W (författare)
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Adams, Robert (författare)
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Azizi, Fereidoun (författare)
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Gabriel, Rafael (författare)
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Gill, Tiffany K (författare)
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Gonzalez, Clicerio (författare)
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Hodge, Allison (författare)
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Jacobs Jr, David R (författare)
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Joseph, Joshua J (författare)
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Khalili, Davood (författare)
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Magliano, Dianna J (författare)
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- Mehlig, Kirsten, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Milne, Roger (författare)
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Mishra, Gita (författare)
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Mongraw-Chaffin, Morgana (författare)
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Pasco, Julie A (författare)
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Sakurai, Masaru (författare)
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Schreiner, Pamela J (författare)
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Selvin, Elizabeth (författare)
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Shaw, Jonathan E (författare)
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Wittert, Gary (författare)
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Yatsuya, Hiroshi (författare)
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Huxley, Rachel R (författare)
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(creator_code:org_t)
- 2019-12-29
- 2019
- Engelska.
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Ingår i: BMJ open diabetes research & care. - : BMJ. - 2052-4897. ; 7:1
- Relaterad länk:
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https://drc.bmj.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful.We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points.Sixteen studies, with 76513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6mmol/L, 2-hour postload glucose 7.0mmol/L and HbA1c 5.6% (38 mmol/mol).In terms of identifying individuals at greatest risk of developing diabetes within 5years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- Av författaren/redakt...
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Lee, Crystal Man ...
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Colagiuri, Steph ...
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Woodward, Mark
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Gregg, Edward W
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Adams, Robert
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Azizi, Fereidoun
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visa fler...
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Gabriel, Rafael
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Gill, Tiffany K
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Gonzalez, Clicer ...
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Hodge, Allison
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Jacobs Jr, David ...
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Joseph, Joshua J
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Khalili, Davood
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Magliano, Dianna ...
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Mehlig, Kirsten, ...
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Milne, Roger
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Mishra, Gita
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Mongraw-Chaffin, ...
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Pasco, Julie A
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Sakurai, Masaru
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Schreiner, Pamel ...
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Selvin, Elizabet ...
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Shaw, Jonathan E
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Wittert, Gary
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Yatsuya, Hiroshi
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Huxley, Rachel R
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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BMJ open diabete ...
- Av lärosätet
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Göteborgs universitet