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Cardiac expression ...
Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia
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- Klevstig, Martina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Arif, Muhammad (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Mannila, M. (author)
- Karolinska Institutet
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- Svedlund, S. (author)
- Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Clin Physiol, Gothenburg, Sweden.
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- Mardani, Ismena (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Ståhlman, Marcus, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Andersson, Linda, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Lindbom, Malin, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Miljanovic, Azra, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Franco-Cereceda, A. (author)
- Karolinska Institutet
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- Eriksson, P. (author)
- Karolinska Institutet
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- Jeppsson, Anders, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Gan, Li-Ming, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,AstraZeneca AB,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.;AstraZeneca R&D, Cardiovasc Renal & Metab IMED Biotech Unit, Molndal, Sweden.
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- Levin, Malin, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Mardinoglu, Adil, 1982 (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Ehrenborg, E. (author)
- Karolinska Institutet
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- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Journal of Molecular and Cellular Cardiology. - : Elsevier BV. - 0022-2828 .- 1095-8584. ; 137, s. 1-8
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Aims: The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods: We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression of the MTTP-A isoform of MTTP. Results: Our results indicate that lower cardiac MTTP expression in humans is associated with structural and perfusion abnormalities in patients with ischemic heart disease. MTTP-A deficiency in mice heart does not affect total MTTP expression, activity or lipid concentration in the heart. Despite this, MTTP-A deficient mice displayed impaired cardiac function after a myocardial infarction. Expression analysis of MTTP indicates that MTTP expression is linked to cardiac function and responses in the heart. Conclusions: Our results indicate that MTTP may play an important role for the heart function in conjunction to ischemic events.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- MTTP
- Polymorphism
- Heart
- Expression
- Function
- apolipoprotein-b
- gene
- cholesterol
- association
- secretion
- variants
- promoter
- overexpression
- identification
- lipoproteins
- Cardiovascular System & Cardiology
- Cell Biology
- Heart
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Klevstig, Martin ...
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Arif, Muhammad
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Mannila, M.
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Svedlund, S.
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Mardani, Ismena
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Ståhlman, Marcus ...
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show more...
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Andersson, Linda ...
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Lindbom, Malin, ...
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Miljanovic, Azra ...
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Franco-Cereceda, ...
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Eriksson, P.
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Jeppsson, Anders ...
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Gan, Li-Ming, 19 ...
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Levin, Malin, 19 ...
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Mardinoglu, Adil ...
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Ehrenborg, E.
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Borén, Jan, 1963
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Journal of Molec ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Royal Institute of Technology
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Karolinska Institutet