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Being overweight in...
Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?
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- Johannessen, A. (author)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway
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- Lønnebotn, M. (author)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway
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- Calciano, L. (author)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy
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- Benediktsdóttir, B. (author)
- Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland
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- Bertelsen, R. J. (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway,Tartu Univ Hosp, Lung Clin, Tartu, Estonia
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- Bråbäck, Lennart (author)
- Umeå universitet,Avdelningen för hållbar hälsa,Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umeå, Sweden
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- Dharmage, S. (author)
- Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
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- Franklin, Karl A (author)
- Umeå universitet,Kirurgi,Umeå Univ, Surg, Dept Surg & Perioperat Sci, Umeå, Sweden
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- Gislason, T. (author)
- Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland
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- Holm, M. (author)
- Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Jarvis, D. (author)
- Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England
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Jõgi, R. (author)
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- Kim, Jeong-Lim (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden
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- Kirkeleit, J. (author)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway
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- Lodge, C. (author)
- Univ Melbourne, Dept Populat Hlth, Melbourne, Vic, Australia
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Klinisk fysiologi
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- Martinez-Moratalla, J. (author)
- CHUA, Serv Neurol, Serv Salud Castilla La Mancha SESCAM, Albacete, Spain
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- Nilsen, R. M. (author)
- Bergen Univ Coll, Dept Nursing, Bergen, Norway
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- Pereira-Vega, A. (author)
- Hosp Juan Ramon Jimenez, Pneumol Sect, Huelva, Spain
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- Real, F. G. (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway
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- Schlünssen, V. (author)
- Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark
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- Accordini, S. (author)
- Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy
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- Svanes, C. (author)
- Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 145:3
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health. © 2019 The Authors
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Ageing Lungs in European Cohorts study
- epidemiology
- multilevel mediation model
- offspring
- parental risk factors
- Ageing Lungs in European Cohorts study
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johannessen, A.
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Lønnebotn, M.
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Calciano, L.
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Benediktsdóttir, ...
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Bertelsen, R. J.
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Bråbäck, Lennart
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show more...
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Dharmage, S.
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Franklin, Karl A
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Gislason, T.
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Holm, M.
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Janson, Christer
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Jarvis, D.
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Jõgi, R.
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Kim, Jeong-Lim
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Kirkeleit, J.
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Lodge, C.
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Malinovschi, And ...
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Martinez-Moratal ...
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Nilsen, R. M.
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Pereira-Vega, A.
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Real, F. G.
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Schlünssen, V.
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Accordini, S.
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Svanes, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- Articles in the publication
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Journal of Aller ...
- By the university
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University of Gothenburg
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Umeå University
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Uppsala University