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  • Johannessen, A.Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway (författare)

Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2020

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/289671
  • https://gup.ub.gu.se/publication/289671URI
  • https://doi.org/10.1016/j.jaci.2019.08.030DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170419URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-410139URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health. © 2019 The Authors

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lønnebotn, M.Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway (författare)
  • Calciano, L.Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy (författare)
  • Benediktsdóttir, B.Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland (författare)
  • Bertelsen, R. J.Univ Bergen, Dept Clin Sci, Bergen, Norway,Tartu Univ Hosp, Lung Clin, Tartu, Estonia (författare)
  • Bråbäck, LennartUmeå universitet,Avdelningen för hållbar hälsa,Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umeå, Sweden(Swepub:umu)lebr0005 (författare)
  • Dharmage, S.Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia (författare)
  • Franklin, Karl AUmeå universitet,Kirurgi,Umeå Univ, Surg, Dept Surg & Perioperat Sci, Umeå, Sweden(Swepub:umu)kafr0021 (författare)
  • Gislason, T.Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland (författare)
  • Holm, M.Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden (författare)
  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (författare)
  • Jarvis, D.Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England (författare)
  • Jõgi, R. (författare)
  • Kim, Jeong-LimGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden(Swepub:gu)xkimje (författare)
  • Kirkeleit, J.Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway (författare)
  • Lodge, C.Univ Melbourne, Dept Populat Hlth, Melbourne, Vic, Australia (författare)
  • Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi(Swepub:uu)anmal535 (författare)
  • Martinez-Moratalla, J.CHUA, Serv Neurol, Serv Salud Castilla La Mancha SESCAM, Albacete, Spain (författare)
  • Nilsen, R. M.Bergen Univ Coll, Dept Nursing, Bergen, Norway (författare)
  • Pereira-Vega, A.Hosp Juan Ramon Jimenez, Pneumol Sect, Huelva, Spain (författare)
  • Real, F. G.Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway (författare)
  • Schlünssen, V.Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark (författare)
  • Accordini, S.Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy (författare)
  • Svanes, C.Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway (författare)
  • Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, NorwayUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Allergy and Clinical Immunology: Elsevier BV145:30091-67491097-6825

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