Incretin hormones, insulin, glucagon and advanced glycation end products in relation to cognitive function in older people with and without diabetes, a population-based study

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Dybjer, E.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden (författare)

Incretin hormones, insulin, glucagon and advanced glycation end products in relation to cognitive function in older people with and without diabetes, a population-based study

Artikel/kapitelEngelska2020

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2020-02-26
Wiley,2020

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LIBRIS-ID:oai:gup.ub.gu.se/291059
https://gup.ub.gu.se/publication/291059URI
https://doi.org/10.1111/dme.14267DOI
https://lup.lub.lu.se/record/b95948c1-ac5b-4685-aa95-57ddb5bbebb9URI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-164620URI

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Språk:engelska

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Funding Agencies|Research Council of Sweden [K2011-65X-20752-04-6]; Anders Palsson Foundation; Ernhold Lundstrom Foundation; Skane County Council; Lund University; Swedish Alzheimers Foundation (Alzheimerfonden); Region Skane
Aim The aim of this observational study was to investigate relationships between physiological levels of glucometabolic biomarkers and cognitive test results in a population-based setting. Methods Cross-sectional data were obtained from the Swedish population-based Malmo Diet and Cancer Study Re-examination 2007-2012 comprising 3001 older people (mean age 72 years). Through oral glucose tolerance testing (OGTT), fasting and post-load levels of serum insulin, plasma glucagon, serum glucose-dependent insulinotropic peptide (GIP) and plasma glucagon-like peptide-1 (GLP-1) were measured. Insulin resistance and insulin sensitivity levels were calculated. In 454 participants, advanced glycation end products (AGEs) were estimated through skin autofluorescence. Associations between biomarkers and two cognitive tests, the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT) respectively, were explored in multiple regression analyses. Results Positive associations following adjustments for known prognostic factors were found between MMSE scores and insulin sensitivity (B = 0.822, P = 0.004), 2-h plasma glucagon (B = 0.596, P = 0.026), 2-h serum GIP (B = 0.581, P = 0.040) and 2-h plasma GLP-1 (B = 0.585, P = 0.038), whereas negative associations were found between MMSE scores and insulin resistance (B = -0.734, P = 0.006), fasting plasma GLP-1 (B = -0.544, P = 0.033) and AGEs (B = -1.459, P = 0.030) were found. Conclusions Higher levels of insulin sensitivity, GIP and GLP-1 were associated with better cognitive outcomes, but AGEs were associated with worse outcomes, supporting evidence from preclinical studies. Glucagon was linked to better outcomes, which could possibly reflect neuroprotective properties similar to the related biomarker GLP-1 which has similar intracellular properties. Longitudinal and interventional studies are needed to further evaluate neuromodulating effects of these biomarkers. presented at the European Association for the Study of Diabetes (EASD) 2019, Barcelona, Spain

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
mental-state-examination
malmo diet
peptide-1
progression
validation
resistance
dementia
glucose
Endocrinology & Metabolism

Biuppslag (personer, institutioner, konferenser, titlar ...)

Engström, G.Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)smi-gen (författare)
Helmer, C.University of Bordeaux,Univ Bordeaux, France (författare)
Nägga, K.Linköping University,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Region Östergötland, Medicinska och geriatriska akutkliniken,Lund Univ, Sweden(Swepub:liu)katna61 (författare)
Rorsman, Patrik,1959Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,University of Oxford,Sahlgrenska Academy,Univ Gothenburg, Sweden; Univ Oxford, England(Swepub:gu)xrorpa (författare)
Nilsson, P. M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)medf-pni (författare)
Internmedicin - epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

Ingår i:Diabetic Medicine: Wiley37:7, s. 1157-11660742-30711464-5491

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Av författaren/redakt...: Dybjer, E.; Engström, G.; Helmer, C.; Nägga, K.; Rorsman, Patrik, ...; Nilsson, P. M.

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Av lärosätet: Göteborgs universitet; Lunds universitet; Linköpings universitet

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