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- Beckmann, K. (författare)
Radical radiotherapy for prostate cancer: patterns of care in Sweden 1998-2016
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
- 2020-03-03
- Informa UK Limited,2020
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/291165
- https://gup.ub.gu.se/publication/291165URI
- https://doi.org/10.1080/0284186x.2020.1730003DOI
Kompletterande språkuppgifter
- Språk:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Introduction: Radiotherapy is an established treatment option for prostate cancer (PCa), both as primary treatment and secondary treatment after radical prostatectomy (RP). Since 1998, detailed data on radiotherapy delivered to Swedish men with PCa (e.g. treatment modalities, absorbed doses, fractionation) have been collated within PCa data Base Sweden (PCBaSe). This study reports patterns of radical radiotherapy for PCa in Sweden over the past two decades. Materials and methods: All men with non-metastatic PCa (1998-2016) who received external beam radiotherapy (EBRT) or high or low dose-rate brachytherapy (HDR-BT/LDR-BT) were identified in PCBaSe. Analyses included: trends in radiation techniques, fractionation patterns and total doses over time; PCa-specific survival comparing treatment in 2007-2017 with 1998-2006; and regional variation in type of primary radiotherapy. Results: About 20,876 men underwent primary radiotherapy. The main treatment modalities include conventionally fractionated (2.0 Gy/fraction) EBRT (51%), EBRT with HDR-BT boost (27%) and hypofractionated (>2.4 Gy/fraction) EBRT (11%). EBRT with photon or proton boost and HDR-BT and LDR-BT monotherapies were each used minimally. Use of dose-escalated EBRT (>74 Gy) and moderate hypofractionation increased over time, while use of HDR-BT declined. Considerable regional variation in treatment modalities was apparent. Risk of PCa death following primary radiotherapy had declined for intermediate-risk (HR: 0.60; 95%CI 0.47-0.87) and high-risk PCa (HR: 0.72; 95%CI 0.61-0.86). Discussion: Increased use of dose escalation and hypofractionated EBRT has occurred in Sweden over the past two decades, reflecting current evidence and practice guidelines. Disease-specific outcomes have also improved. Data collected in PCBaSe provide an excellent resource for further research into RT use in PCa management.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- intensity-modulated radiotherapy
- external-beam radiotherapy
- radiation-therapy
- conformal radiotherapy
- androgen deprivation
- brachytherapy boost
- endocrine treatment
- cohort profile
- dose-response
- register
- Oncology
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Garmo, H. (författare)
- Nilsson, P. (författare)
- Franck Lissbrant, Ingela,1969Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xfranc (författare)
- Widmark, A. (författare)
- Stattin, P. (författare)
- Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Acta Oncologica: Informa UK Limited59:5, s. 549-5570284-186X1651-226X
Internetlänk
Hitta mer i SwePub
- Av författaren/redakt...
- Beckmann, K.
- Garmo, H.
- Nilsson, P.
- Franck Lissbrant ...
- Widmark, A.
- Stattin, P.
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
- Artiklar i publikationen
- Acta Oncologica
- Av lärosätet
- Göteborgs universitet
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