WFRF:(Sims D. A.)
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- Thijssen, E. H. (author)
Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-03-02
- Springer Science and Business Media LLC,2020
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/291234
- https://gup.ub.gu.se/publication/291234URI
- https://doi.org/10.1038/s41591-020-0762-2DOI
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- Language:English
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- SwePubSwePub
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Notes
- Plasma pTau181 concentrations are elevated specifically in patients diagnosed with Alzheimer's disease compared to those diagnosed with frontotemporal lobar degeneration or elderly controls, supporting its further development as a blood-based biomarker for AD. With the potential development of new disease-modifying Alzheimer's disease (AD) therapies, simple, widely available screening tests are needed to identify which individuals, who are experiencing symptoms of cognitive or behavioral decline, should be further evaluated for initiation of treatment. A blood-based test for AD would be a less invasive and less expensive screening tool than the currently approved cerebrospinal fluid or amyloid beta positron emission tomography (PET) diagnostic tests. We examined whether plasma tau phosphorylated at residue 181 (pTau181) could differentiate between clinically diagnosed or autopsy-confirmed AD and frontotemporal lobar degeneration. Plasma pTau181 concentrations were increased by 3.5-fold in AD compared to controls and differentiated AD from both clinically diagnosed (receiver operating characteristic area under the curve of 0.894) and autopsy-confirmed frontotemporal lobar degeneration (area under the curve of 0.878). Plasma pTau181 identified individuals who were amyloid beta-PET-positive regardless of clinical diagnosis and correlated with cortical tau protein deposition measured by F-18-flortaucipir PET. Plasma pTau181 may be useful to screen for tau pathology associated with AD.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- positron-emission-tomography
- neurofilament light-chain
- mild cognitive
- impairment
- csf biomarkers
- association workgroups
- national institute
- fluid biomarkers
- amyloid pet
- dementia
- neuropathology
- Biochemistry & Molecular Biology
- Cell Biology
- Research & Experimental
- Medicine
Added entries (persons, corporate bodies, meetings, titles ...)
- La Joie, R. (author)
- Wolf, A. (author)
- Strom, A. (author)
- Wang, P. (author)
- Iaccarino, L. (author)
- Bourakova, V. (author)
- Cobigo, Y. (author)
- Heuer, H. (author)
- Spina, S. (author)
- VandeVrede, L. (author)
- Chai, X. Y. (author)
- Proctor, N. K. (author)
- Airey, D. C. (author)
- Shcherbinin, S. (author)
- Evans, C. D. (author)
- Sims, J. R. (author)
- Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
- Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
- Karydas, A. M. (author)
- Teunissen, C. E. (author)
- Kramer, J. H. (author)
- Grinberg, L. T. (author)
- Seeley, W. W. (author)
- Rosen, H. (author)
- Boeve, B. F. (author)
- Miller, B. L. (author)
- Rabinovici, G. D. (author)
- Dage, J. L. (author)
- Rojas, J. C. (author)
- Boxer, A. L. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
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- In:Nature Medicine: Springer Science and Business Media LLC26, s. 387-3971078-89561546-170X
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- Bourakova, V.
- Cobigo, Y.
- Heuer, H.
- Spina, S.
- VandeVrede, L.
- Chai, X. Y.
- Proctor, N. K.
- Airey, D. C.
- Shcherbinin, S.
- Evans, C. D.
- Sims, J. R.
- Zetterberg, Henr ...
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- Karydas, A. M.
- Teunissen, C. E.
- Kramer, J. H.
- Grinberg, L. T.
- Seeley, W. W.
- Rosen, H.
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- Dage, J. L.
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- Boxer, A. L.
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