Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives

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Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders.

MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomedicinsk laboratorievetenskap/teknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomedical Laboratory Science/Technology hsv//eng
Gut-brain axis
bile acid
psychiatry
metabolic syndrome
fecal transplantation
germ free
major depressive disorder
autistic spectrum disorders
irritable-bowel-syndrome
time-series analysis
chain fatty-acids
intestinal microbiota
insulin sensitivity
fecal microbiota
tryptophan-metabolism
network perspective
Medical Laboratory Technology
ates of america
v108
p3047
ates of america
v106
p3698

de Clercq, N. C. (författare)
Nieuwdorp, MaxGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xnieum (författare)
Hoenders, H. J. R. (författare)
Groen, A. K. (författare)
Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Ingår i:Critical Reviews in Clinical Laboratory Sciences: Informa UK Limited55:4, s. 283-2931040-83631549-781X

Av författaren/redakt...: Groen, R. N.; de Clercq, N. C.; Nieuwdorp, Max; Hoenders, H. J. ...; Groen, A. K.

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...; och Biomedicinsk lab ...

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