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Sökning: id:"swepub:oai:gup.ub.gu.se/292362" > Outcome and determi...

  • Wästerlid, ToveKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)

Outcome and determinants of failure to complete primary R-CHOP treatment for reasons other than non-response among patients with diffuse large B-cell lymphoma

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-04-03
  • Wiley,2020

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/292362
  • https://gup.ub.gu.se/publication/292362URI
  • https://doi.org/10.1002/ajh.25789DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423834URI
  • https://lup.lub.lu.se/record/8f33c5a4-f783-4395-b79c-97ddc64cb3c2URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143338191URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Patients with diffuse large B-cell lymphoma (DLBCL) who fail to complete planned treatment with R-CHOP due to toxicity are sparsely described. We investigated the extent of failure to complete treatment (six cycles or more, or three cycles + RT for patients with stage I disease) with R-CHOP for reasons unrelated to non-response, the determinants of such failure and the outcome among these patients. Three thousand one hundred and forty nine adult DLBCL patients who started primary treatment with R-CHOP were identified through the Swedish lymphoma register 2007-2014. Of these, 147 (5%) stopped prematurely after 1-3 cycles of R-CHOP for reasons unrelated to non-response, 168 (5%) after 4-5 cycles and 2639 patients (84%) completed planned treatment. Additionally, 195 (6%) patients did not complete treatment due to non-response or death before treatment end. In a multivariable logistic regression model, age > 75 years, poor performance status, extranodal disease and Charlson Comorbidity Index >= 1 were significantly associated with failure to complete planned R-CHOP treatment for other reasons than non-response. Non-completion of treatment strongly correlated with survival. Five-year overall survival for patients who received 1-3 cycles was 26% (95% CI: 19%-33%), 49% (95% CI: 41%-57%) for 4-5 cycles and 76% (74%-77%) for patients who completed treatment. Failure to complete planned R-CHOP treatment is an important clinical issue associated with inferior survival. Old age and poor performance status most strongly predict such failure. These results indicate a need for improved treatment tailoring for patients with certain baseline demographics to improve tolerability and chance for treatment completion.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Harrysson, S.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
  • Andersson, T. M. L.Karolinska Institutet,Karolinska Institute (författare)
  • Ekberg, S.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital (författare)
  • Enblad, GunillaUppsala universitet,Experimentell och klinisk onkologi,Uppsala University Hospital(Swepub:uu)gunienbl (författare)
  • Andersson, Per-Ola,1964University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,South Alvsborg Hosp, Dept Hematol, Borås, Sweden; Gothenburg Univ, Sahlgrenska Acad, Gothenburg, Sweden,South Elfsborg Hospital(Swepub:gu)xapert (författare)
  • Jerkeman, MatsLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-mje (författare)
  • Eloranta, S.Karolinska Institutet,Karolinska Institute (författare)
  • Smedby, K. E. (författare)
  • Karolinska InstituteKarolinska University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Hematology: Wiley95:7, s. 740-7480361-86091096-8652

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