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Outcome and determi...
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Wästerlid, ToveKarolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
Outcome and determinants of failure to complete primary R-CHOP treatment for reasons other than non-response among patients with diffuse large B-cell lymphoma
- Artikel/kapitelEngelska2020
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LIBRIS-ID:oai:gup.ub.gu.se/292362
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https://gup.ub.gu.se/publication/292362URI
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https://doi.org/10.1002/ajh.25789DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423834URI
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https://lup.lub.lu.se/record/8f33c5a4-f783-4395-b79c-97ddc64cb3c2URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143338191URI
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Patients with diffuse large B-cell lymphoma (DLBCL) who fail to complete planned treatment with R-CHOP due to toxicity are sparsely described. We investigated the extent of failure to complete treatment (six cycles or more, or three cycles + RT for patients with stage I disease) with R-CHOP for reasons unrelated to non-response, the determinants of such failure and the outcome among these patients. Three thousand one hundred and forty nine adult DLBCL patients who started primary treatment with R-CHOP were identified through the Swedish lymphoma register 2007-2014. Of these, 147 (5%) stopped prematurely after 1-3 cycles of R-CHOP for reasons unrelated to non-response, 168 (5%) after 4-5 cycles and 2639 patients (84%) completed planned treatment. Additionally, 195 (6%) patients did not complete treatment due to non-response or death before treatment end. In a multivariable logistic regression model, age > 75 years, poor performance status, extranodal disease and Charlson Comorbidity Index >= 1 were significantly associated with failure to complete planned R-CHOP treatment for other reasons than non-response. Non-completion of treatment strongly correlated with survival. Five-year overall survival for patients who received 1-3 cycles was 26% (95% CI: 19%-33%), 49% (95% CI: 41%-57%) for 4-5 cycles and 76% (74%-77%) for patients who completed treatment. Failure to complete planned R-CHOP treatment is an important clinical issue associated with inferior survival. Old age and poor performance status most strongly predict such failure. These results indicate a need for improved treatment tailoring for patients with certain baseline demographics to improve tolerability and chance for treatment completion.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Harrysson, S.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
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Andersson, T. M. L.Karolinska Institutet,Karolinska Institute
(författare)
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Ekberg, S.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
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Enblad, GunillaUppsala universitet,Experimentell och klinisk onkologi,Uppsala University Hospital(Swepub:uu)gunienbl
(författare)
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Andersson, Per-Ola,1964University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,South Alvsborg Hosp, Dept Hematol, Borås, Sweden; Gothenburg Univ, Sahlgrenska Acad, Gothenburg, Sweden,South Elfsborg Hospital(Swepub:gu)xapert
(författare)
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Jerkeman, MatsLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-mje
(författare)
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Eloranta, S.Karolinska Institutet,Karolinska Institute
(författare)
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Smedby, K. E.
(författare)
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Karolinska InstituteKarolinska University Hospital
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Journal of Hematology: Wiley95:7, s. 740-7480361-86091096-8652
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