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  • Aghanavesi, Somayeh,1981-Högskolan Dalarna,Mikrodataanalys,Dalarna Univ, Dept Comp Engn, Falun, Sweden. (författare)

A multiple motion sensors index for motor state quantification in Parkinson's disease

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2020

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/293256
  • https://gup.ub.gu.se/publication/293256URI
  • https://doi.org/10.1016/j.cmpb.2019.105309DOI
  • https://research.chalmers.se/publication/515200URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-78860URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-31738URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413458URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Aim: To construct a Treatment Response Index from Multiple Sensors (TRIMS) for quantification of motor state in patients with Parkinson's disease (PD) during a single levodopa dose. Another aim was to compare TRIMS to sensor indexes derived from individual motor tasks. Method: Nineteen PD patients performed three motor tests including leg agility, pronation-supination movement of hands, and walking in a clinic while wearing inertial measurement unit sensors on their wrists and ankles. They performed the tests repeatedly before and after taking 150% of their individual oral levodopa-carbidopa equivalent morning dose.Three neurologists blinded to treatment status, viewed patients’ videos and rated their motor symptoms, dyskinesia, overall motor state based on selected items of Unified PD Rating Scale (UPDRS) part III, Dyskinesia scale, and Treatment Response Scale (TRS). To build TRIMS, out of initially 178 extracted features from upper- and lower-limbs data, 39 features were selected by stepwise regression method and were used as input to support vector machines to be mapped to mean reference TRS scores using 10-fold cross-validation method. Test-retest reliability, responsiveness to medication, and correlation to TRS as well as other UPDRS items were evaluated for TRIMS. Results: The correlation of TRIMS with TRS was 0.93. TRIMS had good test-retest reliability (ICC = 0.83). Responsiveness of the TRIMS to medication was good compared to TRS indicating its power in capturing the treatment effects. TRIMS was highly correlated to dyskinesia (R = 0.85), bradykinesia (R = 0.84) and gait (R = 0.79) UPDRS items. Correlation of sensor index from the upper-limb to TRS was 0.89. Conclusion: Using the fusion of upper- and lower-limbs sensor data to construct TRIMS provided accurate PD motor states estimation and responsive to treatment. In addition, quantification of upper-limb sensor data during walking test provided strong results. © 2019

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Westin, JerkerHögskolan Dalarna,Datateknik,Dalarna Univ, Dept Comp Engn, Falun, Sweden.(Swepub:du)jwe (författare)
  • Bergquist, Filip,1970Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,University of Gothenburg,Department of Pharmacology at Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Pharmacol, Inst Neurosci & Physiol, Gothenburg, Sweden.(Swepub:gu)xberfi (författare)
  • Nyholm, DagUppsala universitet,Landtblom: Neurovetenskap(Swepub:uu)danyh856 (författare)
  • Askmark, HåkanUppsala universitet,Landtblom: Neurovetenskap(Swepub:uu)hakaaskm (författare)
  • Memedi, Mevludin,PhD,1983-Örebro universitet,Handelshögskolan vid Örebro Universitet,Informatics,Orebro Univ, Informat, Orebro, Sweden.(Swepub:oru)mnmi (författare)
  • Constantinescu, Radu,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,University of Gothenburg,Department of Clinical Neuroscience, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Clin Neurosci, Gothenburg, Sweden.(Swepub:gu)xconra (författare)
  • Medvedev, Alexander,1958-Uppsala universitet,Reglerteknik,Avdelningen för systemteknik(Swepub:uu)almed173 (författare)
  • Spira, J.Sensidose AB, Sollentuna, Sweden. (författare)
  • Ohlsson, Fredrik,1983Chalmers tekniska högskola,Chalmers University of Technology,Department of Sensor Systems at Acreo Swedish ICT, Kista, Sweden,Chalmers Univ, Gothenburg, Sweden.(Swepub:cth)freohl (författare)
  • Thomas, IliasHögskolan Dalarna,Mikrodataanalys,Dalarna Univ, Dept Stat, Falun, Sweden.(Swepub:du)ith (författare)
  • Ericsson, A.Department of Clinical Neuroscience and Rehabilitation, University of Gothenburg, Gothenburg, Sweden,Irisity AB, Gothenburg, Sweden. (författare)
  • Johansson Buvarp, DongniGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg,Irisity AB, Gothenburg,Univ Gothenburg, Dept Clin Neurosci & Rehabil, Gothenburg, Sweden.(Swepub:gu)xjodon (författare)
  • Memedi, M. (författare)
  • Aquilonius, Sten-MagnusUppsala universitet,Landtblom: Neurovetenskap(Swepub:uu)stenaqui (författare)
  • Högskolan DalarnaMikrodataanalys (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Computer Methods and Programs in Biomedicine: Elsevier BV1890169-26071872-7565

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