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The Association Bet...
The Association Between General Childhood Psychopathology and Adolescent Suicide Attempt and Self-Harm: A Prospective, Population-Based Twin Study
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- O'Reilly, L. M. (författare)
- Indiana University, Department of Psychological and Brain Sciences, Bloomington IN, USA
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- Pettersson, E. (författare)
- Karolinska Institutet
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- Quinn, P. D. (författare)
- Indiana University, Department of Applied Health Science, Bloomington IN, USA
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- Klonsky, E. D. (författare)
- University of British Columbia, Department of Psychology, Vancouver BC, Canada
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- Lundström, Sebastian (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg, Department of Psychiatry and Neurochemistry, Gothenburg, Sweden
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- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Solna, Sweden
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- Lichtenstein, P. (författare)
- Karolinska Institutet
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- D'Onofrio, B. M. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-05
- 2020
- Engelska.
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Ingår i: Journal of Abnormal Psychology. - : American Psychological Association (APA). - 0021-843X .- 1939-1846. ; 129:4, s. 364-375
- Relaterad länk:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Few quantitative behavior genetic studies have examined why psychopathology is associated with suicide attempt (SA) and self-harm (SH) in adolescence. The present study analyzed data from the Child and Adolescent Twin Study in Sweden to examine the extent to which genetic and environmental factors explain SA/SH and its association with psychopathology in childhood, an often-cited risk factor of subsequent SA/SH. When children were 9 or 12 years old (n = 30,444), parents completed the Autism-Tics, AD/HD and other Comorbidities Inventory (Larson et al., 2010) regarding their children's psychiatric problems as part of an ongoing, longitudinal study. At age 18 years (n = 10,269), adolescents completed self-report questionnaires, including SA/SH assessments. In a bifactor model of childhood psychopathology, a general factor of psychopathology was a statistically significant predictor of adolescvnt SA/SH at a higher magnitude (beta, 0.25, 95% confidence interval [CI; 0.15, 0.34] for suicide attempt), as compared with specific factors of inattention, impulsivity, oppositional behavior, and anxiety/emotion symptoms. Quantitative genetic modeling indicated that the additive genetic influences on the general factor accounted for the association with each outcome (beta, 0.24, 95% CI [0.13, 0.34] for suicide attempt). The results remained virtually identical when we fit a higher order factors model. Two additional outcomes demonstrated comparable results. The results extend current literature by revealing the shared genetic overlap between general psychopathology during childhood and adolescent SA/SH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- suicide attempt
- self-harm
- adolescence
- twin design
- general
- psychopathology factor
- comorbidities a-tac
- bifactor model
- risk-factors
- environmental
- contributions
- telephone interview
- autism-tics
- behavior
- ideation
- disorders
- variance
- Psychology
- Psychiatry
- suicide attempt
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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