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Mechanically ventilated patients exhibit decreased particle flow in exhaled breath as compared to normal breathing patients

Broberg, Ellen (författare)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnanestesi och intensivvård,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric anesthesia and intensive care,Lund University Research Groups,Skåne University Hospital
Andreasson, Jesper (författare)
Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,DCD transplantation av lungor,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,DCD transplantation of lungs,Lund University Research Groups,Skåne University Hospital
Fakhro, Mohammed (författare)
Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,DCD transplantation av lungor,Forskargrupper vid Lunds universitet,Klinisk och experimentell lungtransplantation,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,DCD transplantation of lungs,Lund University Research Groups,Clinical and experimental lung transplantation,Skåne University Hospital
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Olin, Anna-Carin, 1960 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska Academy
Wagner, Darcy (författare)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Lungbioengineering och regeneration,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lung Bioengineering and Regeneration,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine
Hyllén, Snejana (författare)
Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Minimalinvasiv hjärtkirurgi vid hjärtklaffsjukdom,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Minimal invasive cardiac surgery in valvular heart disease,Lund University Research Groups,Skåne University Hospital
Lindstedt, Sandra (författare)
Lund University,Lunds universitet,DCD transplantation av lungor,Forskargrupper vid Lunds universitet,Klinisk och experimentell lungtransplantation,Lungbioengineering och regeneration,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,DCD transplantation of lungs,Lund University Research Groups,Clinical and experimental lung transplantation,Lung Bioengineering and Regeneration,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital
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 (creator_code:org_t)
2020-02-10
2020
Engelska.
Ingår i: Erj Open Research. - : European Respiratory Society (ERS). - 2312-0541. ; 6:1
Relaterad länk:
https://openres.ersj...
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http://dx.doi.org/10... (free)
https://gup.ub.gu.se...
https://doi.org/10.1...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Introduction: In this cohort study, we evaluated whether the particles in exhaled air (PExA) device can be used in conjunction with mechanical ventilation during surgery. The PExA device consists of an optical particle counter and an impactor that collects particles in exhaled air. Our aim was to establish the feasibility of the PExA device in combination with mechanical ventilation (MV) during surgery and if collected particles could be analysed. Patients with and without nonsmall cell lung cancer (NSCLC) undergoing lung surgery were compared to normal breathing (NB) patients with NSCLC. Methods: A total of 32 patients were included, 17 patients with NSCLC (MV-NSCLC), nine patients without NSCLC (MV-C) and six patients with NSCLC and not intubated (NB). The PEx samples were analysed for the most common phospholipids in surfactant using liquid-chromatography-mass-spectrometry (LCMS). Results: MV-NSCLC and MV-C had significantly lower numbers of particles exhaled per minute ( particle flow rate; PFR) compared to NB. MV-NSCLC and MV-C also had a siginificantly lower amount of phospholipids in PEx when compared to NB. MV-NSCLC had a significantly lower amount of surfactant A compared to NB. Conclusion: We have established the feasibility of the PExA device. Particles could be collected and analysed. We observed lower PFR from MV compared to NB. High PFR during MV may be due to more frequent opening and closing of the airways, known to be harmful to the lung. Online use of the PExA device might be used to monitor and personalise settings for mechanical ventilation to lower the risk of lung damage.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

pulmonary surfactant
lung injury

Publikations- och innehållstyp

ref (ämneskategori)
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