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  • Tataranno, M. L.Wilhelmina Children’s Hospital,Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands. (author)

Morphine affects brain activity and volumes in preterms: An observational multi-center study

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/294409
  • https://gup.ub.gu.se/publication/294409URI
  • https://doi.org/10.1016/j.earlhumdev.2020.104970DOI
  • https://lup.lub.lu.se/record/b49dc296-20fd-4944-93fc-a3935862e963URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418219URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective: We hypothesized that morphine has a depressing effect on early brain activity, assessed using quantitative aEEG/EEG parameter and depressed activity will be associated with brain volumes at term in extremely preterm infants. Study design: 174 preterm infants were enrolled in 3 European tertiary NICUs (mean GA:26 +/- 1wks) and monitored during the first 72 h after birth with continuous 2 channel aEEG. Six epochs of aEEG recordings were selected and minimum amplitude of aEEG (min aEEG), percentage of time amplitude< 5 mu V (% of time < 5 mu V), spontaneous activity transients (SATrate) and interSAT interval (ISI) were calculated. For infants receiving morphine, the cumulative morphine dosage was calculated. In a subgroup of 58 infants, good quality MRI at term equivalent age (TEA) and the cumulative morphine dose until TEA were available. The effects of morphine administration and cumulative dose on aEEG/EEG measures and on brain volumes were investigated. Results: Morphine administration had a significant effect on all quantitative aEEG/EEG measures, causing depression of early brain activity [longer ISI (beta 2.900), reduced SAT rate (beta -1.386), decreased min aEEG (beta -0.782), and increased % of time < 5 mu V (beta 14.802)] in all epochs. A significant effect of GA and postnatal age on aEEG/EEG measures was observed. Cumulative morphine dose until TEA had a significant negative effect on total brain volume (TBV) (beta -8.066) and cerebellar volume (beta -1.080). Conclusions: Administration of sedative drugs should be considered when interpreting aEEG/EEG together with the negative dose dependent morphine impact on brain development.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Gui, L.University of Geneva,Univ Geneva, Dept Pediat, Div Dev & Growth, Geneva, Switzerland. (author)
  • Hellström-Westas, L.Uppsala universitet,Uppsala University,Perinatal, neonatal och barnkardiologisk forskning(Swepub:uu)lenwe671 (author)
  • Toet, M.Wilhelmina Children’s Hospital,Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands. (author)
  • Groenendaal, F.Wilhelmina Children’s Hospital,Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands. (author)
  • Claessens, N. H. P.Wilhelmina Children’s Hospital,University of Geneva,Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands.,Univ Geneva, Dept Pediat, Div Dev & Growth, Geneva, Switzerland. (author)
  • Schuurmans, J.Wilhelmina Children’s Hospital,Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands. (author)
  • Fellman, V.Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Pediat, Lund, Sweden.(Swepub:lu)pedi-vfe (author)
  • Sävman, Karin,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrenska Academy,Univ Gothenburg, Sahlgrenska Acad, Perinatal Ctr, Inst Clin Sci,Dept Pediat, Gothenburg, Sweden.(Swepub:gu)xsavka (author)
  • de Vries, L. S.Wilhelmina Children’s Hospital,Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands. (author)
  • Huppi, P. (author)
  • Benders, MjnlWilhelmina Children’s Hospital,Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands. (author)
  • Wilhelmina Children’s HospitalUniv Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands. (creator_code:org_t)

Related titles

  • In:Early Human Development: Elsevier BV1440378-37821872-6232

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