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- Hoang Philipsen, Thuy Mai,1988Chalmers tekniska högskola,Chalmers University of Technology (author)
Zinc Deficiency Leads to Lipid Changes in Drosophila Brain Similar to Cognitive-Impairing Drugs: An Imaging Mass Spectrometry Study
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-06-16
- Wiley,2020
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/294620
- https://gup.ub.gu.se/publication/294620URI
- https://doi.org/10.1002/cbic.202000197DOI
- https://research.chalmers.se/publication/519558URI
- https://research.chalmers.se/publication/517743URI
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- Language:English
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Notes
- Several diseases and disorders have been suggested to be associated with zinc deficiency, especially learning and memory impairment. To have better understanding about the connection between lipid changes and cognitive impairments, we investigated the effects of a zinc-chelated diet on certain brain lipids ofDrosophila melanogasterby using time-of-flight secondary ion mass spectrometry (ToF-SIMS). The data revealed that there are increases in the levels of phosphatidylcholine and phosphatidylinositol in the central brains of the zinc-deficient flies compared to the control flies. In contrast, the abundance of phosphatidylethanolamine in the brains of the zinc-deficient flies is lower. These data are consistent with that of cognitive-diminishing drugs, thus providing insight into the biological and molecular effects of zinc deficiency on the major brain lipids and opening a new treatment target for cognitive deficit in zinc deficiency.
Subject headings and genre
- NATURVETENSKAP Kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences hsv//eng
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- cognition
- Drosophila melanogaster
- lipid changes
- mass spectrometry
- imaging
- zinc deficiency
- saccharomyces-cerevisiae
- phospholipid-synthesis
- tof
- release
- damage
- Biochemistry & Molecular Biology
- Pharmacology & Pharmacy
- Drosophila melanogaster
Added entries (persons, corporate bodies, meetings, titles ...)
- Gu, Chaoyi,1992Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:gu)xgucha (author)
- Ewing, Andrew G,1957Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:gu)xewian (author)
- Chalmers tekniska högskolaInstitutionen för kemi och molekylärbiologi (creator_code:org_t)
Related titles
- In:Chembiochem: Wiley21:19, s. 2755-27581439-42271439-7633
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