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Fluorene exposure a...
Fluorene exposure among PAH-exposed workers is associated with epigenetic markers related to lung cancer
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- Alhamdow, Ayman (författare)
- Karolinska Institute
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- Essig, Y. J. (författare)
- Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
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- Krais, Annette M. (författare)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Gustavsson, P. (författare)
- Karolinska Institutet,Karolinska Institute
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- Tinnerberg, Håkan, 1965 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,School of Public Health and Community Medicine, Section of Occupational and Environmental Medicine, University of Gothenburg Sahlgrenska Academy, Göteborg, Sweden
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- Lindh, Christian H. (författare)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Hagberg, Jessika, 1974- (författare)
- Örebro University,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine,MTM Research Centre
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- Graff, P. (författare)
- Department of Chemical and Biological Work Environment, STAMI, Oslo, Norway,National Institute of Occupational Health, Norway
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- Albin, Maria (författare)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Arbetsorganisation och hälsa,Forskargrupper vid Lunds universitet,Environmental health and occupational health,Lund University Research Groups,Stockholm Regional Council
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- Broberg, Karin (författare)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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(creator_code:org_t)
- 2020-05-08
- 2020
- Engelska.
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Ingår i: Occupational and Environmental Medicine. - : BMJ. - 1351-0711 .- 1470-7926. ; 77:7, s. 488-495
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Abstract
Ämnesord
Stäng
- Objectives Exposure to high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) may cause cancer in chimney sweeps and creosote-exposed workers, however, knowledge about exposure to low-molecular-weight PAHs in relation to cancer risk is limited. In this study, we aimed to investigate occupational exposure to the low-molecular-weight PAHs phenanthrene and fluorene in relation to different cancer biomarkers. Methods We recruited 151 chimney sweeps, 19 creosote-exposed workers and 152 unexposed workers (controls), all men. We measured monohydroxylated metabolites of phenanthrene and fluorene in urine using liquid chromatography coupled to tandem mass spectrometry. We measured, in peripheral blood, the cancer biomarkers telomere length and mitochondrial DNA copy number using quantitative PCR; and DNA methylation ofF2RL3andAHRRusing pyrosequencing. Results Median PAH metabolite concentrations were higher among chimney sweeps (up to 3 times) and creosote-exposed workers (up to 353 times), compared with controls (p<0.001; adjusted for age and smoking). n-ary sumation OH-fluorene (sum of 2-hydroxyfluorene and 3-hydroxyfluorene) showed inverse associations with percentage DNA methylation ofF2RL3andAHRRin chimney sweeps (B (95% CI)=-2.7 (-3.9 to -1.5) forF2RL3_cg03636183, and -7.1 (-9.6 to -4.7) forAHRR_cg05575921: adjusted for age and smoking), but not in creosote-exposed workers. In addition, n-ary sumation OH-fluorene showed a 42% mediation effect on the inverse association between being a chimney sweep and DNA methylation ofAHRRCpG2. Conclusions Chimney sweeps and creosote-exposed workers were occupationally exposed to low-molecular-weight PAHs. Increasing fluorene exposure, among chimney sweeps, was associated with lower DNA methylation ofF2RL3andAHRR, markers for increased lung cancer risk. These findings warrant further investigation of fluorene exposure and toxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- smoking
- health care workers
- risk assessment
- cross sectional studies
- cancer
- polycyclic aromatic-hydrocarbons
- occupational-exposure
- 1-hydroxypyrene
- metabolites
- pyrene
- Public
- Environmental & Occupational Health
- Cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Alhamdow, Ayman
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Essig, Y. J.
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Krais, Annette M ...
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Gustavsson, P.
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Tinnerberg, Håka ...
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Lindh, Christian ...
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Hagberg, Jessika ...
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Graff, P.
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Albin, Maria
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Broberg, Karin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Cancer och onkol ...
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Occupational and ...
- Av lärosätet
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Göteborgs universitet
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Örebro universitet
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Lunds universitet
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Karolinska Institutet