Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

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MARC

Strakova, A. (author)

Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

Article/chapterEnglish2020

Publisher, publication year, extent ...

2020-06-16
Springer Science and Business Media LLC,2020

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/294859
https://gup.ub.gu.se/publication/294859URI
https://doi.org/10.1038/s41467-020-16765-wDOI

Supplementary language notes

Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
phylogenetic analysis
genome
transcription
sequence
dog
variants
dynamics
health
cell
tool
Science & Technology - Other Topics

Added entries (persons, corporate bodies, meetings, titles ...)

Nicholls, Thomas J.Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine (author)
Baez-Ortega, A. (author)
Ni Leathlobhair, M. (author)
Sampson, A. T. (author)
Hughes, K. (author)
Bolton, I. A. G. (author)
Gori, K. (author)
Wang, J. H. (author)
Airikkala-Otter, I. (author)
Allen, J. L. (author)
Allum, K. M. (author)
Arnold, C. L. (author)
Bansse-Issa, L. (author)
Bhutia, T. N. (author)
Bisson, J. L. (author)
Blank, K. (author)
Briceno, C. (author)
Domracheva, A. C. (author)
Corrigan, A. M. (author)
Cran, H. R. (author)
Crawford, J. T. (author)
Cutter, S. M. (author)
Davis, E. (author)
de Castro, K. F. (author)
De Nardi, A. B. (author)
de Vos, A. P. (author)
Keena, L. D. (author)
Donelan, E. M. (author)
Huerta, A. R. E. (author)
Faramade, I. A. (author)
Fazil, M. (author)
Fotopoulou, E. (author)
Fruean, S. N. (author)
Gallardo-Arrieta, F. (author)
Glebova, O. (author)
Gouletsou, P. G. (author)
Hafelin Manrique, R. F. (author)
Henriques, Jjgp (author)
Horta, R. S. (author)
Ignatenko, N. (author)
Kane, Y. (author)
King, C. (author)
Koenig, D. (author)
Krupa, A. (author)
Kruzeniski, S. J. (author)
Lanza-Perea, M. (author)
Lazyan, M. (author)
Quintana, A. M. L. (author)
Losfelt, T. (author)
Marino, G. (author)
Martinez Castaneda, S. (author)
Martinez-Lopez, M. F. (author)
Masuruli, B. M. (author)
Meyer, M. (author)
Migneco, E. J. (author)
Nakanwagi, B. (author)
Neal, K. B. (author)
Neunzig, W. (author)
Nixon, S. J. (author)
Ortega-Pacheco, A. (author)
Pedraza-Ordonez, F. (author)
Peleteiro, M. C. (author)
Polak, K. (author)
Pye, R. J. (author)
Ramirez-Ante, J. C. (author)
Reece, J. F. (author)
Gutierrez, J. R. (author)
Sadia, H. (author)
Schmeling, S. K. (author)
Shamanova, O. (author)
Sherlock, A. G. (author)
Steenland-Smit, A. E. (author)
Svitich, A. (author)
Tapia Martinez, L. J. (author)
Ngoka, I. T. (author)
Torres, C. G. (author)
Tudor, E. M. (author)
van der Wel, M. G. (author)
Vitalaru, B. A. (author)
Vural, S. A. (author)
Walkinton, O. (author)
Wehrle-Martinez, A. S. (author)
Widdowson, S. A. E. (author)
Zvarich, I. (author)
Chinnery, P. F. (author)
Falkenberg, M. (author)
Gustafsson, C. M. (author)
Murchison, E. P. (author)
Göteborgs universitetInstitutionen för biomedicin (creator_code:org_t)

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By the author/editor: Strakova, A.; Nicholls, Thomas ...; Baez-Ortega, A.; Ni Leathlobhair, ...; Sampson, A. T.; Hughes, K.; show more...; Bolton, I. A. G.; Gori, K.; Wang, J. H.; Airikkala-Otter, ...; Allen, J. L.; Allum, K. M.; Arnold, C. L.; Bansse-Issa, L.; Bhutia, T. N.; Bisson, J. L.; Blank, K.; Briceno, C.; Domracheva, A. C ...; Corrigan, A. M.; Cran, H. R.; Crawford, J. T.; Cutter, S. M.; Davis, E.; de Castro, K. F.; De Nardi, A. B.; de Vos, A. P.; Keena, L. D.; Donelan, E. M.; Huerta, A. R. E.; Faramade, I. A.; Fazil, M.; Fotopoulou, E.; Fruean, S. N.; Gallardo-Arrieta ...; Glebova, O.; Gouletsou, P. G.; Hafelin Manrique ...; Henriques, Jjgp; Horta, R. S.; Ignatenko, N.; Kane, Y.; King, C.; Koenig, D.; Krupa, A.; Kruzeniski, S. J ...; Lanza-Perea, M.; Lazyan, M.; Quintana, A. M. ...; Losfelt, T.; Marino, G.; Martinez Castane ...; Martinez-Lopez, ...; Masuruli, B. M.; Meyer, M.; Migneco, E. J.; Nakanwagi, B.; Neal, K. B.; Neunzig, W.; Nixon, S. J.; Ortega-Pacheco, ...; Pedraza-Ordonez, ...; Peleteiro, M. C.; Polak, K.; Pye, R. J.; Ramirez-Ante, J. ...; Reece, J. F.; Gutierrez, J. R.; Sadia, H.; Schmeling, S. K.; Shamanova, O.; Sherlock, A. G.; Steenland-Smit, ...; Svitich, A.; Tapia Martinez, ...; Ngoka, I. T.; Torres, C. G.; Tudor, E. M.; van der Wel, M. ...; Vitalaru, B. A.; Vural, S. A.; Walkinton, O.; Wehrle-Martinez, ...; Widdowson, S. A. ...; Zvarich, I.; Chinnery, P. F.; Falkenberg, M.; Gustafsson, C. M ...; Murchison, E. P.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Nature Communica ...

By the university: University of Gothenburg

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