House Dust Mite Induces Bone Marrow IL-33-Responsive ILC2s and T-H Cells

• Type 2 innate lymphoid cells (ILC2s) and their adaptive counterpart type 2 T helper (T(H)2) cells respond to interleukin-33 (IL-33) by producing IL-5, which is a crucial cytokine for eosinophil development in the bone marrow. The aim of this study was to determine if bone marrow ILC2s, T-H cells, and eosinophils are locally regulated by IL-33 in terms of number and activation upon exposure to the common aeroallergen house dust mite (HDM). Mice that were sensitized and challenged with HDM by intranasal exposures induced eosinophil development in the bone marrow with an initial increase of IL5R alpha(+) eosinophil progenitors, following elevated numbers of mature eosinophils and the induction of airway eosinophilia. Bone marrow ILC2s, T(H)2, and eosinophils all responded to HDM challenge by increased IL-33 receptor (ST2) expression. However, only ILC2s, but not T-H cells, revealed increased ST2 expression at the onset of eosinophil development, which significantly correlated with the number of eosinophil progenitors. In summary, our findings suggest that airway allergen challenges with HDM activates IL-33-responsive ILC2s, T-H cells, and eosinophils locally in the bone marrow. Targeting the IL-33/ST2 axis in allergic diseases including asthma may be beneficial by decreasing eosinophil production in the bone marrow.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

IL-33

ST2

asthma

allergy

IL-5

innate lymphoid cells

T helper

cells

type 2 inflammation

eosinophilia

adaptive immunity

innate lymphoid-cells

allergic airways disease

receptor expression

il-33

inflammation

interleukin-5

immunity

t(h)2

eosinophils

regulators

Biochemistry & Molecular Biology

Chemistry

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